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CDKN1A — HSPB1

Text-mined interactions from Literome

O'Callaghan-Sunol et al., Cancer Res 2007 (Breast Neoplasms...) : The protection was associated with suppression of the doxorubicin induced senescence, where Hsp27 inhibited p53 mediated induction of p21 , the major regulator of the senescence program ... Similarly, Hsp27 inhibited accumulation of p21 and suppressed senescence in response to the p53 activator nutlin-3, indicating that Hsp27 has a general effect on the p53 pathway
Xu et al., Cell Signal 2013 : Furthermore, phosphorylated Hsp27 increased p53 nuclear importing and its downstream target gene expression such as p21 and MDM2, while de-phosphorylated Hsp27 impeded this procession