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AKT1 — RUNX2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Fujita et al., J Cell Biol 2004
:
Runx2 up-regulated PI3K subunits ( p85 and p110beta ) and
Akt , and their expression patterns were similar to that of Runx2 in growth plates
Qiao et al., J Biol Chem 2004
:
Surprisingly, these IGF-1 mediated effects on
RUNX2 were not
regulated by
Akt phosphorylation, a common downstream target of PI3K, as determined by pharmacological or genetic inhibition
Komori et al., Clinical calcium 2006
:
Phosphoinositide 3-kinase (PI3K)-Akt signaling enhances DNA binding of Runx2 and Runx2 dependent transcription, and
Runx2 upregulates PI3K subunits ( p85 and p110 beta ) and
Akt
Byon et al., J Biol Chem 2008
(Atherosclerosis...) :
Inhibition of H2O2 activated
AKT signaling
blocked VSMC calcification and
Runx2 induction concurrently ... Taken together, our data demonstrate a critical role for
AKT mediated induction of
Runx2 in oxidative stress induced VSMC calcification
Liu et al., Biochem Biophys Res Commun 2013
:
Furthermore, in the presence of exogenous BMP-2, PI3K and
Akt inhibitors
blocked Runx2 and osteocalcin expression, although BMP-2 did not activate Akt