Felton et al., Am J Physiol Lung Cell Mol Physiol 2009
:
We investigated the effects of N-acetylcysteine (NAC) on TGF-beta1 induced EMT in a rat epithelial cell line ( RLE-6TN ) and in primary rat alveolar epithelial cells ( AEC ) ... We conclude that NAC prevents EMT in AEC in vitro, at least in part through replenishment of intracellular GSH stores and limitation of TGF-beta1 induced intracellular ROS generation ... We speculate that beneficial effects of NAC on pulmonary function in IPF may be mediated by inhibitory effects on alveolar EMT Shimojo et al., Clin Exp Metastasis 2013
(Anoxia...) :
The antioxidants N-acetylcysteine (NAC) and ebselen significantly suppressed EMT and the expression of EMT regulators during hypoxia