Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Dai et al., Hum Reprod 2011 (Pre-Eclampsia) : Both JunB/FosB and p65 were increased in placenta from women with severe pre-eclampsia versus a normal pregnancy, with elevated expression of miR-155 ( P < 0.05 )
Ruan et al., Proc Natl Acad Sci U S A 2011 (Diabetes Mellitus, Type 1) : In pancreatic ß cells, c-Rel and p65 of the NF-?B family activated the mir21 gene promoter and increased miR-21 RNA levels ; miR-21 in turn decreased the level of PDCD4, which is able to induce cell death through the Bax family of apoptotic proteins
Scisciani et al., J Hepatol 2012 (Carcinoma, Hepatocellular...) : Exogenously expressed p65/RelA activates the miR-224 promoter and a dominant negative form of I?Ba ( I?BSR ) represses it
Li et al., BMC molecular biology 2012 (Esophageal Neoplasms) : Mutation two of these KB sites impaired p65 induced miR-34a transcriptional activity ... In addition, we found that overexpression of NF-kappaB p65 could not successfully induce miR-34a expression in esophageal cancer cell lines with mutant p53 or decreased p53