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EGFR — ITGA6

Pathways - manually collected, often from reviews:

• NCI Pathway Database a6b1 and a6b4 Integrin signaling: EGF/EGFR complex (EGF-EGFR) → alpha6/beta4 Integrin complex (ITGA6-ITGB4) (modification, activates)
  Russell et al., J Cell Sci 2003, Yoon et al., Cancer Res 2006
  Evidence: assay

Text-mined interactions from Literome

Yoon et al., Cancer Res 2006 (Breast Neoplasms...) : ErbB2, a binding partner of epidermal growth factor receptor (EGFR), and EGFR modulated Ras activity, and integrin alpha(6)beta ( 4 ) regulated phospho-EGFR level without affecting EGFR expression ... In summary, we propose a novel mechanism for ErbB2 up-regulation and Ras activation in serum depleted breast cancer cells ; integrin alpha(6)beta ( 4 ) regulates the expression of ErbB2 and the subsequent phosphorylation of EGFR and activation of Ras
Wang et al., Cancer Res 2009 (Breast Neoplasms) : Knockdown of TACE, FAK, or integrin alpha(6) by siRNA or inhibition of EGFR or Src by specific inhibitors abrogated TGF-beta induced receptor clustering and signaling to phosphatidylinositol 3-kinase-Akt
Chen et al., Mol Cell Biol 2010 : Thus, integrin alpha1beta1 negatively regulates EGFR activation by positively controlling Cav-1 levels, and the ERK/PPARgamma axis plays a key role in regulating integrin alpha1beta1 dependent Cav-1 expression and consequent EGFR mediated ROS production