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CXCL12 — SETD2

Text-mined interactions from Literome

Ceradini et al., Nat Med 2004 (Disease Models, Animal...) : Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 ... Here we show that SDF-1 gene expression is regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1) in endothelial cells, resulting in selective in vivo expression of SDF-1 in ischemic tissue in direct proportion to reduced oxygen tension ... HIF-1 induced SDF-1 expression increases the adhesion, migration and homing of circulating CXCR4 positive progenitor cells to ischemic tissue ... These data show that the recruitment of CXCR4 positive progenitor cells to regenerating tissues is mediated by hypoxic gradients via HIF-1 induced expression of SDF-1
Chang et al., Cell Transplant 2007 (Stroke) : SDF-1 gene expression is regulated by hypoxic-inducible factor-1 (HIF-1) , a hypoxia dependent stabilization transcription factor
Nemenoff et al., Circ Res 2008 (Hyperplasia...) : SDF-1alpha production by other cell types is regulated by the transcription factor hypoxia-inducible factor (HIF)-1alpha
Hoenig et al., Curr Mol Med 2008 (Ischemia...) : HIF-1 , the master regulator or neovascularization, regulates the expression of vascular endothelial growth factor ( VEGF ), stromal cell derived factor-1 (SDF-1) and CXC chemokine Receptor-4 (CXCR4)
Kioi et al., J Clin Invest 2010 (Brain Neoplasms...) : Previous studies have indicated that BMDCs are recruited to tumors in part through the interaction between the HIF-1 dependent stromal cell derived factor-1 (SDF-1) and its receptor, CXCR4
Kojima et al., Blood 2011 (Leukemia, Myeloid, Acute) : p53 activation of mesenchymal stromal cells partially abrogates microenvironment mediated resistance to FLT3 inhibition in AML through HIF-1a mediated down-regulation of CXCL12