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CHUK — PRKCB

Pathways - manually collected, often from reviews:

• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: IKK complex complex (CHUK-IKBKB-IKBKG) → PKC beta (PRKCB) (modification, collaborate)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: CHUK — PRKCB (in vitro) Saijo et al., J Exp Med 2002*

Text-mined interactions from Literome

Saijo et al., J Exp Med 2002 : Using mice deficient for protein kinase C beta (PKCbeta) we show an essential role of PKCbeta in the phosphorylation of IKKalpha and the subsequent activation of NF-kappaB in B cells
Su et al., Nat Immunol 2002 (Lymphoma, B-Cell) : PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling
Trushin et al., Mol Cell Biol 2003 : Herein, we demonstrate using genetic analysis, pharmacological inhibition, and RNA interference ( RNAi ) that the conventional protein kinase C ( PKC ) isoform PKCalpha, but not PKCbeta1 , is required for the activation of the IKK complex following T-cell activation triggered by CD3/CD28 cross linking
Guo et al., Curr Opin Immunol 2004 : Recent evidence indicates that PKCbeta might regulate inhibitor of kappaB kinase (IKK) and NF-kappaB activation through interaction with the CARMA1/Bcl10/MALT signaling complex in BCR microdomains