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CA2 — MAPK11
Text-mined interactions from Literome
Liu et al., Brain Res Mol Brain Res 1999
:
All together, these results indicate that
MAPK is implicated in the transmission of AMPA signaling to the nucleus and
requires extracellular
Ca2+ , and PLC/PKC activation
Zhang et al., J Immunol 1999
:
However, p38
MAPK is
activated strongly and synergistically by either CD3/CD28 coligation or
PMA/Ca2+ ionophore stimulation, which mimics TCR-CD3/CD28 mediated signaling
Tauskela et al., Brain Res 1999
(Brain Ischemia...) :
Ca2+ influx and
activation of protein kinase C ( PKC ) and
mitogen activated protein kinase ( MAPK ) during nonlethal ischemic preconditioning have been implicated in the protection of the heart against subsequent lethal ischemic injury
Huang et al., Cell Signal 1999
:
Involvement of intermediary metabolites in the pathway of extracellular
Ca2+ induced
mitogen activated protein kinase activation in human fibroblasts ...
Ca2+ induced
MAPK activation was partly abolished by treatment of the cells with pertussis toxin
Wang et al., Mol Endocrinol 1999
(Pituitary Neoplasms) :
These studies are consistent with a signaling pathway involving PKC- and
Ca2+ dependent activation of
MAPK , which leads to phosphorylation of an Ets transcription factor and activation of the PRL promoter
Huang et al., Eur J Biochem 1999
:
Extra Ca2+ stimulated phosphorylation/activation of p42/p44 mitogen activated protein kinases by an initially ( 10 min ) zinc independent mechanism ; however, insulin, and particularly zinc, significantly prolonged
Ca2+ induced
mitogen activated protein kinase phosphorylation
Conrad et al., Adv Exp Med Biol 2000
:
Role of
Ca2+/CaM in the activation of
MAPK and p38 gamma
Waltereit et al., J Neurosci 2001
:
Arg3.1/Arc mRNA induction by
Ca2+ and cAMP
requires protein kinase A and
mitogen activated protein kinase/extracellular regulated kinase activation
Fueta et al., Life Sci 2002
:
Hyperexcitability and changes in activities of
Ca2+/calmodulin dependent kinase II and
mitogen activated protein kinase in the hippocampus of rats exposed to 1-bromopropane ... We studied whether the hyperexcitability is associated with changes of
Ca2+/calmodulin dependent kinase II ( CaMKII ),
mitogen activated protein kinase ( MAPK ), and protein kinase C ( PKC )
Schäfer et al., FASEB J 2003
(Calcium Signaling...) :
Transient hypoxic inhibition of mitochondria induces a proliferative endothelial response mediated through Ca2+ independent activation and
Ca2+ dependent nuclear translocation of p42
MAPK
Sorensen et al., Mol Pharmacol 2003
:
Comparison of the intracellular signaling pathways of glial PAR-1, LPA, and S1P receptors indicates that each receptor class activates multiple downstream signaling pathways, including Gq/11 directed inositol
lipid/Ca2+ signaling, Gi/o
activation of mitogen activated protein kinases (
MAPK ) ( extracellular signal regulated kinase 1/2 and stress activated protein kinase/c-jun N-terminal kinase, but not p38 ), and activation of Rho pathways
Olszewska-Pazdrak et al., J Biol Chem 2004
:
We report a novel mechanism for amplitude modulation of
[Ca2+ ] ( i ) that
involves mitogen activated protein kinase ( MAPK )
Ye et al., J Neurosci Res 2004
:
Here we show that elevated
Ca2+ ( o )
stimulates extracellular-signal regulated kinase ( ERK1/2 ) and p38
MAP kinase ( MAPK ) ... The
effect of high
Ca2+ ( o ) on p38
MAPK but not ERK1/2 is CaR mediated, insofar as transduction with a dominant negative CaR ( R185Q ) using recombinant adeno associated virus ( rAAV ) attenuated the activation of p38 MAPK but not of ERK1/2
Hilgenberg et al., J Neurobiol 2004
:
Ca2+ release from intracellular stores
activates both calcium/calmodulin dependent kinase II ( CaMKII ) and mitogen activated protein kinase (
MAPK )
Kim et al., Eur J Pharmacol 2005
(Hypertension) :
Thus, basal vascular tone is elevated by the altered activation of
MAPK in DOCA-salt hypertensive rats, and this is
regulated by PKC, but not by Rho or intracellular
Ca2+
Poeckel et al., J Pharmacol Exp Ther 2006
:
3-O-acetyl-11-keto-boswellic acid decreases basal intracellular
Ca2+ levels and
inhibits agonist induced Ca2+ mobilization and
mitogen activated protein kinase activation in human monocytic cells
Kumada et al., J Neurosci 2006
(Disease Models, Animal...) :
Each second messenger has multiple but distinct downstream targets, including
Ca2+/calmodulin dependent protein kinase II, calcineurin, protein phosphatase 1, Rho GTPase,
mitogen activated protein kinase , and phosphoinositide 3-kinase
Bourguignon et al., J Biol Chem 2006
(Carcinoma, Squamous Cell...) :
Overexpression of the LARG-PDZ domain also functions as a dominant negative mutant ( similar to the
PLC/Ca2+-calmodulin dependent kinase II ( CaMKII ) and
EGFR/MAPK inhibitor effects ) to block HA/CD44 mediated signaling events ( e.g. EGFR kinase activation, Ras/RhoA co-activation, Raf-ERK signaling, PLC epsilon mediated inositol 1,4,5-triphosphate production, intracellular Ca2+ mobilization, CaMKII activity, filamin phosphorylation, and filamin-actin binding ) and to abrogate tumor cell growth/migration
Hodges et al., Invest Ophthalmol Vis Sci 2006
:
Roles of protein kinase C,
Ca2+ , Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44
MAPK
Zhang et al., J Physiol 2007
:
The effect was blocked by alpha7-nAChR antagonists, by chelation of intracellular Ca2+ with BAPTA, and by inhibition of both
Ca2+-calmodulin dependent protein kinase II and
mitogen activated protein kinase
Wang et al., J Biol Chem 2009
(Carcinoma, Hepatocellular) :
Here we report that melittin can induce apoptosis of HCC cells by activating
Ca2+/calmodulin dependent protein kinase, transforming growth factor-beta activated kinase 1 ( TAK1 ), and JNK/p38
MAPK
Donnellan et al., Am J Physiol Gastrointest Liver Physiol 2010
(MAP Kinase Signaling System) :
These data demonstrate a novel
role for JNK
MAPK in regulating
Ca2+ but not cAMP dependent epithelial Cl ( - ) secretion
Huang et al., Biochem J 1995
:
Activation of
MAPK by extracellular
Ca2+ was dose dependent and biphasic, with a peak of activation at 5-10 min after exposure, followed by a period of sustained activation of MAPK at a lower level
Ito et al., Cell Growth Differ 1994
:
The two putative isoforms of the cholecystokinin-B/gastrin receptor expressed in mouse fibroblasts showed the same characteristics in their ligand-bindings, the major signal transduction such as phosphoinositides production, cytoplasmic
Ca2+ increase, tyrosine phosphorylation of focal adhesion kinase,
activation of
mitogen activated protein kinase , and the induction of early-responsive genes such as c-fos, c-myc, and c-jun
Hansen et al., J Biol Chem 1996
:
Tyrosine phosphorylation was not required for GH stimulation of
mitogen activated protein ( MAP ) kinase activity or for GH-stimulated
Ca2+ channel
activation since these pathways were normal in cells expressing a GH receptor in which all eight intracellular tyrosines were mutated to phenylalanines
Miralem et al., J Biol Chem 1996
:
We conclude that heparin suppresses induction of c-fos in mesangial cells by blocking at least two different points in signal transduction cascades, one upstream of
MAPK and the other independent of MAPK, but
dependent on intracellular
Ca2+
Duesbery et al., Zygote 1996
:
The
role of microtubules and inositol triphosphate induced
Ca2+ release in the tyrosine phosphorylation of
mitogen activated protein kinase in extracts of Xenopus laevis oocytes
Fiorucci et al., Gastroenterology 1996
:
The aim of this study was to investigate whether EGF modulates pepsinogen release and intracellular
Ca2+ concentrations ([Ca2+]i) and whether the effect
involves mitogen activated protein ( MAP ) kinase , eicosanoid generation, and nitric oxide
Suzuki et al., Nihon Shinkei Seishin Yakurigaku Zasshi 1996
(Synaptic Transmission) :
I review in this article the two groups of PSD proteins : Protein kinases (
Ca2+/calmodulin dependent protein kinase II, protein kinase C,
mitogen activated protein kinase , and tyrosine kinases ) and molecules that work as messengers from the synapse to the nucleus ( MSNs )
Muthalif et al., J Biol Chem 1996
:
We have investigated the contribution of
Ca2+/calmodulin dependent protein kinase II ( CaM kinase II ) and
mitogen activated protein kinase ( MAP kinase ) in norepinephrine ( NE ) -induced arachidonic acid ( AA ) release in rabbit aortic vascular smooth muscle cells ( VSMC )
Franklin et al., Am J Physiol 1997
:
Eliminating extracellular
Ca2+ had no effect on phorbol 12,13-dibutyrate ( PDBu ) -dependent contractions or
MAPK activity ; however, KCl dependent contractions and MAPK activity were completely abolished by this procedure
Seewald et al., J Hypertens 1997
:
The
role of platelet derived growth factor-BB induced increase in cytosolic free
Ca2+ in activation of
mitogen activated protein kinase and DNA synthesis in vascular smooth muscle cells
Tian et al., Endocrinology 1998
:
Although neither Ca2+ influx nor
Ca2+ release from intracellular stores was
sufficient to activate
MAPK , Ca2+ appeared to play a permissive role in this response
Eguchi et al., J Biol Chem 1998
:
We have recently reported that angiotensin II (Ang II) induced
mitogen activated protein kinase ( MAPK ) activation is mainly
mediated by
Ca2+ dependent activation of a protein tyrosine kinase through Gq-coupled Ang II type 1 receptor in cultured rat vascular smooth muscle cells ( VSMC )
Wotta et al., Pharmacology 1998
:
Activation of
MAPK at the M1, M3 and M5 muscarinic receptor subtypes was not
dependent on intracellular or extracellular
Ca2+ , but was partially dependent upon protein kinase C
Samanta et al., J Neurochem 1998
:
H2O2 alone strongly enhanced the levels of immunodetectable activated
mitogen activated protein kinase ( activated MAP kinases ERK1 and ERK2 ) in a
Ca2+ dependent manner and this effect was additive with increases in the levels of activated MAP kinase evoked by glutamate
Maulon et al., Blood 1998
:
Our results are consistent with a negative role for p56Lck on thrombin
induced [
Ca2+ ] i release and p38
MAPK activation in Jurkat T-cell lines
Zhang et al., J Physiol 1998
:
Involvement of tyrosine kinases,
Ca2+ and PKC in activation of
mitogen activated protein ( MAP ) kinase in human polymorphonuclear neutrophils
Chin et al., Am J Physiol 1998
:
SPC induced
MAPK activation was blocked by treatment of cells with the phospholipase C inhibitor, U-73122, or the intracellular Ca2+-ATPase inhibitor, thapsigargin, but not by removal of extracellular
Ca2+ ... Our results suggest that, in porcine aortic smooth muscle cells,
MAPK is not
activated by the increase in [
Ca2+ ] i unless a pertussis toxin-sensitive G protein is simultaneously stimulated, indicating the role of Ca2+ in pertussis toxin-sensitive G protein mediated MAPK activation