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CDC42 — PTK2
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
PTK2
→
CDC42
(reaction)
Shekarabi et al., Mol Cell Neurosci 2002, Cory et al., J Biol Chem 2002, Wu et al., J Biol Chem 2004, Shekarabi et al., J Neurosci 2005
-
Reactome Reaction:
PTK2
→
CDC42
(indirect_complex)
Shekarabi et al., Mol Cell Neurosci 2002, Shekarabi et al., J Neurosci 2005
Text-mined interactions from Literome
Xue et al., Int J Cancer 2006
(Carcinoma, Hepatocellular...) :
The hypoxia stimulated activities of Rac1 and
Cdc42 could be
blocked by the phosphatidylinositol 3'-kinase (PI3K) inhibitor LY294002 and the
protein tyrosine kinase ( PTK ) inhibitor genistein but were not affected by the p38MAPK inhibitor SB203580 or the MEK-1 inhibitor PD98059, suggesting that the hypoxia mediated signals were through PI3K and PTK ... Our results indicate that PI3K and
PTK mediated activations of Rac1 and
Cdc42 are involved in the hypoxia induced production of angiogenesis promoting factors and tumor suppressors, and suggest that the Rho family GTPases Rac1 and Cdc42 may contribute to the hypoxia mediated angiogenesis
Park et al., Biochim Biophys Acta 2013
:
In conclusion, C ( 16 ) -Cer enhances mouse ESC migration through the regulation of PKC and
FAK/Paxillin dependent
N-WASP/Cdc42/Arp2/3 complex formation as well as through promoting the interaction between cofilin-1 or a-actinin-1/-4 and F-actin