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IL1A — MMP2

Text-mined interactions from Literome

Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Lotz et al., Rheum Dis Clin North Am 1999 (Arthritis...) : NO also may be involved as a mediator of IL-1 induced expression of MMP , mRNA, and protein and may contribute as an activator of the latent forms of the enzymes
van Meurs et al., J Immunol 1999 (Arthritis...) : In vitro studies showed that SLN-1 is also pivotally involved in IL-1 induced MMP activity
Origuchi et al., Clin Exp Rheumatol 2000 (Arthritis, Rheumatoid) : MMP-2 is not secreted by rheumatoid osteoblasts as a proenzyme ; however, IL-1 beta stimulation induced the secretion of MMP-2 as an active form from rheumatoid osteoblasts ... In support of this result, IL-1 beta stimulation induced the expression of membrane type matrix-metalloproteinase ( MT-MMP ), a newly identified MMP-2 specific activator, in rheumatoid osteoblasts
Shlopov et al., J Rheumatol 2001 (Osteoarthritis) : A decrease in IL-1alpha , IL-1beta, and IL-6 would reduce stimulation of MMP production, while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves
Miyajima et al., Microb Pathog 2001 (Corneal Ulcer...) : Effects of pseudomonal virulence factors [ elastase, alkaline protease, exotoxin A and lipopolysaccharide (LPS) ], tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta on MMP induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ), zymography and immunoblotting
Kut-Lasserre et al., J Periodontol 2001 (Periodontitis) : As anticipated, IL-1beta induced a marked release of MMP-2 , MMP-3, and TIMP-1, but no variation for TIMP-2 was seen
Kubota et al., J Dent Res 2002 (Odontogenic Cysts) : In this study, we investigated the effects of IL-1alpha on the activation of matrix metalloproteinase-2 (MMP-2) in the fibroblasts isolated from odontogenic keratocysts
Elliott et al., Arthritis Res Ther 2003 (Bone Neoplasms...) : To quantify the effects of CDDO on IL-1 induced MMP-1, MMP-13 and Bcl-3 expression, we stimulated the chondrosarcoma cell line SW-1353 and human primary chondrocytes with IL-1, in the presence or absence of CDDO
Lorenzo et al., Matrix 1992 : In addition TPA and IL-1 also increased 72-kDa gelatinase activity ... In unstimulated osteoblast-like MC3T3-E1 cell cultures 72-kDa gelatinase enzyme activity was much greater than 92-kDa activity and was not substantially regulated ( less than 40 % change ) by IL-1 , TNF or PTH
Kaden et al., Atherosclerosis 2003 (Aortic Valve Stenosis) : As recent studies have suggested that calcific AS might result from an inflammatory process involving leukocyte invasion and activation, the present study aimed to elucidate the role of the pro-inflammatory cytokine interleukin (IL)-1 beta on MMP expression and cell proliferation in human aortic valves
Smith et al., Br J Ophthalmol 2004 : IL-1alpha and LPS had no effect on MMP/TIMP production by cultured corneal epithelial cells and keratocytes
Dayer et al., Reumatismo 2004 (Arthritis, Rheumatoid) : IL-1 and TNF-alpha are potent inducers of matrix metalloproteinases ( MMP ) , eicosanoids, nitric oxide oxydase ( iNOS ), receptor activator of NF-kB ligand ( RANKL ), products involved in the destruction of the extracellular matrix, the cartilage and in bone resorption
Kobayashi et al., Arthritis Rheum 2005 (Osteoarthritis, Knee) : Independent analyses of gene expression in cultured cartilage from 9 other OA patients revealed that IL-1 or TNFalpha blockade, either alone and/or in combination, frequently down-regulated MMP-1, MMP-3 , and MMP-13 expression
Oka et al., J Dent Res 2005 (Jaw Diseases...) : Recombinant human interleukin-1alpha ( rhIL-1alpha ) increased the secretion of MMP-1, MMP-2 , MMP-3, and PGE2 in the fibroblasts
Wang et al., Int J Mol Med 2005 : In this study, we first investigated the effect of IL-1 on MAPK activity, c-Jun and c-Fos mRNA expression, and MMP-1 and MMP-2 production in UVA irradiated human dermal fibroblasts ... IL-1alpha and IL-1beta promoted MMP-1 but not MMP-2 production in UVA irradiated fibroblasts
Guay et al., Reproduction 2007 (Endometriosis) : In these cells, IL1R2 expression was markedly reduced, compared with non transfected cells or cells transfected with the empty vector, and there was a significant increase in the basal and the IL1-beta (IL1B) induced levels of matrix metalloproteinase (MMP)-2 and MMP-9 secretion
Wilusz et al., J Orthop Res 2008 : We used an in vitro model system to examine the hypotheses that acute exposure to IL-1 inhibits meniscal repair, and that an IL-1 mediated increase in matrix metalloproteinase ( MMP ) activity is associated with the inhibition of repair
Guo et al., Int J Cardiol 2008 : The purpose of this study was to determine the ability and possible signal pathway involved of imidaprilat, an ACE inhibitor, to modulate MMP-2 and TIMP-2 in human cardiac fibroblasts in the presence of interleukin (IL)-1beta
McNulty et al., Clin Orthop Relat Res 2009 : In the presence of IL-1 , the broad-spectrum MMP inhibitor GM 6001 decreased the MMP activity in the media, increased the shear strength of repair, and enhanced tissue repair in the interface
Zhang et al., J Surg Res 2009 : The AP-1 siRNA also significantly inhibited PDGF/IL-1 induced MMP-2 and MMP-9 gelatinolytic activity in VSMCs
Vosgerau et al., Biochem Pharmacol 2010 : Treatment of VSMCs with HKa reduced in a concentration dependent manner IL-1alpha induced release of MMP-9 and MMP-2 , associated with decreased MMP enzymatic activity levels in conditioned media, as demonstrated by gelatin zymography and fluorescein labeled gelatin substrate assay, respectively
McNulty et al., Osteoarthritis Cartilage 2010 (Knee Injuries) : IL-1 increased MMP activity, S-GAG release, and NO production, while decreasing the shear strength and tissue repair in the interface
Lemke et al., Cell Tissue Res 2010 (Arthritis) : Significant IL-1 effects were a decrease in biosynthetic activity, an increase in GAG release and in the expression/abundance of MMP-2, MMP-3 and ADAMTS4
Wang et al., J Surg Res 2011 : Protein levels on Western blot paralleled enzyme activity, with the synthesis of more active MMP-2 than pro-MMP-2 in response to IL-1ß
Litherland et al., J Biol Chem 2010 : However, MMP1 and MMP13 induction by IL-1 + OSM was inhibited only by aPKC silencing, suggesting that only atypical isoforms play a significant role in complex inflammatory milieus
Wang et al., J Biol Chem 2010 : We examined adhesion restricted signaling pathways that enable IL-1 induced MMP release in human gingival and murine fibroblasts
García-Arnandis et al., Arthritis Res Ther 2010 (MAP Kinase Signaling System...) : In OA synoviocytes, HMGB1 alone at concentrations of 15 or 25 ng/ml did not affect the production of IL-6, IL-8, CCL2, CCL20, MMP-1 or MMP-3, but in the presence of IL-1ß , a significant potentiation of protein and mRNA expression, as well as MMP activity was observed
Zhang et al., Mol Hum Reprod 2011 : Pretreatment of EcSCs with PDTC attenuated IL-1ß induced expressions of CD44s, MMP-2 , MMP-9 and survivin at gene and protein levels
Hoffmann et al., Biochem Pharmacol 2011 (Adenocarcinoma...) : Proinflammatory IL-6 and PGHS-2 as well as proangiogenic IL-8 and VEGF were induced by IL-1 , whereas the secretion of invasion promoting MMP-2 remained unaffected
Zhang et al., Inflammation 2012 (Arthritis, Rheumatoid...) : IL-1ß or TNF-a increased expression of MMP-9 and MMP-2 in rheumatoid synoviocytes ; EGF stimulated expression of MMP-9 but not of MMP-2 ; genistein suppressed production of MMP-9 more than MMP-2 induced by IL-1ß or TNF-a ; rMMP-9, rMMP-2, or their inhibitors had no effect on the ( 3 ) H-TdR incorporation of synovial cells ... Neither PD098059 nor SP600 125 could inhibit the MMP-2 expression induced by TNF-a or IL-1ß
Toegel et al., Genes & nutrition 2012 : We further observed that the levels of IL1ß induced MMP-1, MMP-3 , MMP-7, and MMP-9 mRNA, but not TIMP mRNA levels, were down-regulated in chondrocytes in response to CSE
Akhtar et al., BMC complementary and alternative medicine 2011 (Osteoarthritis) : Effect of HLM on IL-1ß induced gene expression of iNOS, MMP-9 , MMP-13, ACAN and COL2A1 was verified by real time-PCR
Pecchi et al., Osteoarthritis Cartilage 2012 : IL-1ß increased COX-2, mPGES-1, MMP-3 , MMP-13, RANKL expressions, decreased 15-PGDH expression, and increased PGE2, MMP-3 and MMP-13 release ... Interestingly, 7 days of CS treatment significantly counteracted IL-1ß induced expression of COX-2 ( -62 %, P < 0.001 ), mPGES-1 ( -63 %, P < 0.001 ), MMP-3 ( -39 %, P=0.08 ), MMP-13 ( -60 %, P < 0.001 ) and RANKL ( -84 %, P < 0.001 ) ... Accordingly, IL-1ß induced PGE2, MMP-3 and MMP-13 releases were inhibited by 86 % ( P < 0.001 ), 58 % ( P < 0.001 ) and 38 % ( P < 0.01 ) respectively
Ma et al., Arthritis Rheum 2012 (Wnt Signaling Pathway) : The aim of this study was to investigate the role of Wnt/ß-catenin signaling in interleukin-1ß (IL-1ß) induced MMP expression in human chondrocytes ... Wnt/ß-catenin signaling in human chondrocytes had an unexpected anticatabolic role by counteracting NF-?B mediated MMP expression induced by IL-1ß in a negative feedback loop
Kapral et al., Int J Colorectal Dis 2012 (Colonic Neoplasms...) : Stimulation of cells with IL-1ß only resulted in an overexpression of MMP and their TIMP mRNAs ... After 12 h, IL-1ß induced MMP-2 mRNA expression was significantly reduced by IP6 ... Proinflammatory cytokine IL-1ß upregulates MMP and TIMP mRNAs expression in colon cancer epithelial cells Caco-2
Zhou et al., Invest Ophthalmol Vis Sci 2012 (Disease Models, Animal) : IL-1ß induced MMP expression and activation as well as collagen degradation were also blocked by the p38 MAPK inhibitor SB203580
Fioravanti et al., J Pharmacol Sci 2012 (Osteoarthritis) : The presence of IL-1ß led to a significant increase in PGE ( 2 ), MMP-3 , and NO production, as well as a significant increase in gene expression of COX-2 and iNOS
Bougault et al., Arthritis Rheum 2012 (Disease Models, Animal...) : LPS, IL-1a , and TNFa dose-dependently increased MMP-3, MMP-9 , and MMP-13 activity in cultured chondrocytes and in NLRP3 ( -/- ) chondrocytes, and this effect was not changed by inhibiting caspase 1 or IL-1ß
Petrella et al., Cancer medicine 2012 : Specifically, IL-1ß induced the expression of MMP-1, MMP-3 , MMP-10, and MT1-MMP in a mechanism dependent on IL-1ß activation of the transcription factor CCAAT enhancer binding protein ß ( CEBPß )
Wei et al., Spine (Phila Pa 1976) 2013 : ERK inhibition reversed the changes of protein expression of MMP-3, MMP-13 , TIMP-1, aggrecan and collagen II induced by IL-1
Zeng et al., Exp Cell Res 1994 : Although Il-1 alpha had no significant effect on TIMP-2 mRNA or on expression of 72-kDa gelatinase, in either early or late passage cells, Il-1 alpha increased the level of a TIMP-2-72-kDa gelatinase complex
Rawdanowicz et al., J Clin Endocrinol Metab 1994 : Both interleukin-1 alpha and tumor necrosis factor-alpha stimulated the secretion of MMP-1, MMP-3 , and MMP-9, but not MMP-2, from the cells in a concentration dependent manner
Tamura et al., Endocrinology 1996 (Arthritis...) : Gelatin zymography of the RAC culture medium revealed that IL-1 increased the production of matrix metalloproteinase-2 (MMP-2) and MMP-9
Sato et al., FEBS Lett 1996 : The suppressive effect of IL-1alpha on the TNFalpha induced proMMP-9 production is a new biological effect of IL-1 on MMP production
Kusano et al., Endocrinology 1998 (Bone Resorption) : In mouse calvarial cultures, IL-1 markedly enhanced the messenger RNA ( mRNA ) expression of MMP-13 ( collagenase 3 ), MMP-2 ( gelatinase A ), MMP-9 ( gelatinase B ), and MMP-3 ( stromelysin 1 ), which associated with increases in bone matrix degradation ... In mouse osteoblastic cells, the expression ofMMP-2, MMP-3 , and MMP-13 mRNAs could be detected, and they were markedly enhanced by IL-1alpha on days 2 and 5
Sasaki et al., J Biochem 1998 : IL-1 sequentially stimulated mRNA expression of iNOS, membrane type 1-MMP , MMP-9 and -3, and bFGF, in that order
Andersen et al., Anticancer Res 1998 (Bone Neoplasms...) : The CAPL protein expressed in cell-cultures appear to block the MMP induction by bFGF and Il-1 alpha