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IGF1 — IRF6

Text-mined interactions from Literome

Filipov et al., J Endocrinol 1999 (Cattle Diseases...) : Importantly, however, TNF-alpha, cortisol, and IGF-I responses to LPS were greater in E+ compared with E- steers
Priego et al., J Endocrinol 2002 (Shock, Septic) : The aim of this work was to elucidate the possible role of glucocorticoids in the bacterial lipopolysaccharide (LPS) induced decrease in hepatic IGF-I synthesis ... For this purpose, we studied the effect of LPS on IGF-I in two rat strains, Wistar and Lewis, which have different adrenal responses to inflammation ... These data indicate that the adrenal axis may mediate the inhibitory effect of LPS on GHR and IGF-I synthesis in the liver
Frost et al., Endocrinology 2003 : The purpose of the present study was to determine whether LPS alters the expression of TNF alpha and IGF-I in mouse skeletal muscle and whether TNF alpha directly inhibits IGF-I mRNA expression in C2C12 myoblasts
Priego et al., Am J Physiol Endocrinol Metab 2004 : NO plays a role in LPS induced decreases in circulating IGF-I and IGFBP-3 and their gene expression in the liver ... In this study, we administered aminoguanidine, a relatively selective inducible nitric oxide synthase (iNOS) inhibitor, to study the role of nitric oxide ( NO ) in LPS induced decrease in IGF-I and IGFBP-3 ... The LPS induced decrease in serum concentrations of IGF-I and liver IGF-I gene expression seems to be secondary to iNOS activation, since aminoguanidine administration prevented the effect of LPS on circulating IGF-I and its gene expression in the liver
Granado et al., J Endocrinol 2006 (Body Weight...) : Pretreatment of the animals with gadolinium chloride blocked the inhibitory effect of LPS on body weight, and on serum concentrations of IGF-I, IGFBP-3 and nitrites, as well as growth hormone receptor (GHR), IGF-I and IGFBP-3 gene expression in the liver ... These results suggest that Kupffer cells are important mediators in the inhibitory effect of LPS on GHR, IGF-I and IGFBP-3 gene expression in the liver, leading to a decrease in serum concentrations of IGF-I and IGFBP-3
Priego et al., J Endocrinol 2006 : In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6- ( 1-iminoethyl ) lysine ( l-NIL ) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures ... However, in cocultures, the iNOS inhibitor l-NIL prevented the effect of LPS on nitrite+nitrate levels, but only attenuated the LPS induced decrease in IGF-I gene expression ... We conclude that in hepatocytes, LPS induced decrease in IGF-I is mainly due to induction of iNOS, whereas in the presence of Kupffer cells LPS inhibits IGF-I through NO release and through other inhibitory pathways
Granado et al., Am J Physiol Endocrinol Metab 2008 (Endotoxemia...) : GHRP-2 administration attenuated the effects of LPS on transaminases, nitrites/nitrates, TNF-alpha, and IGF-I in vivo
Crisostomo et al., Am J Physiol Cell Physiol 2008 : TNF-alpha, LPS , and hypoxia significantly increased human MSC VEGF, FGF2, HGF, and IGF-1 production versus controls
Waggoner et al., J Anim Sci 2009 : Diet samples, feed refusals, feces, and urine were collected daily for 5 d. Rectal temperature and serum concentrations of cortisol, prolactin, tumor necrosis factor-alpha, and haptoglobin increased, whereas thyroxine and triiodothyronine decreased for +LPS vs. -LPS steers ( LPS x h ; P < 0.01 ). Plasma urea-N was greater for +LPS than -LPS steers ( LPS ; P = 0.03 ), and serum IGF-1 was not affected ( P > or = 0.26 ) by LPS or Met
Thomsen et al., In Vivo 2008 (Insulin Resistance...) : LPS reduced IGF-I and IGFBP-3 by 20 % in the cirrhosis group
Lin et al., Chang Gung Med J 2010 (Body Weight...) : LPS induced sarcolemmal damage in diaphragm myofibers from 24 h to 96 h, which was accompanied by a significant increase in IL-1ß expression in the tissues while IGF-I levels were down-regulated
Fan et al., Am J Physiol 1995 : Pretreatment with anti-TNF Ab attenuated the LPS induced reduction in IGF-I and the increased IGFBP-1 in plasma and liver and completely prevented the decrease in IGF-I observed in muscle
Arkins et al., Mol Endocrinol 1995 : This effect is specific for IFN gamma because neither the IFNs-alpha/beta nor lipopolysaccharide (LPS) affects expression of steady state IGF-I transcripts