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MYC — PPP2R1A

Text-mined interactions from Literome

Yeh et al., Nat Cell Biol 2004 (Cell Transformation, Neoplastic...) : Furthermore, the absence of Pin1 or inhibition of PP2A stabilizes c-Myc
Chen et al., Mol Cancer Res 2005 (Prostatic Neoplasms) : Thus, the effects of Pim on PP2A activity may mediate the levels of c-Myc and the phosphorylation of proteins needed for increased protein synthesis
Arnold et al., Mol Cell Biol 2006 : PP2A mediates its effects on c-Myc by dephosphorylating a conserved residue that normally stabilizes c-Myc, and in this way, PP2A enhances c-Myc ubiquitin mediated degradation
Guénin et al., Int J Oncol 2008 (Melanoma, Experimental) : In untreated cells, okadaic acid, an antagonist of PP2A methylation, inhibited PP2A activity, stimulated cell proliferation, increased Akt activation and c-Myc expression
Arnold et al., Cancer Metastasis Rev 2008 : This review will focus on the role of PP2A-B56alpha in regulating c-Myc and will place this tumor suppressor activity of PP2A within the context of its other tumor suppressor functions
Mukhopadhyay et al., FASEB J 2009 : Importantly, whereas down-regulation of I2PP2A enhanced PP2A mediated c-Myc degradation in response to ceramide, ectopic expression of wild-type I2PP2A but not of its K209D mutant protected this degradation in A549 cells
Mannava et al., Oncogene 2012 (Melanoma) : Importantly, PP2A-B56a overexpression suppressed C-MYC in melanoma cells and induced OIS, whereas depletion of PP2A-B56a in normal human melanocytes upregulated C-MYC protein levels and suppressed BRAF ( V600E ) - and, less efficiently, NRAS ( Q61R ) -induced senescence