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IL8 — TRAF6
Text-mined interactions from Literome
Lomaga et al., Genes Dev 1999
(Osteopetrosis) :
TRAF6 deficiency
results in osteopetrosis and defective
interleukin-1 , CD40, and LPS signaling
Wang et al., Infect Immun 2001
:
Induction of NF-kappaB was partially inhibited by dominant negative tumor necrosis factor receptor associated kinase 6 ( TRAF6 ) but not TRAF2, whereas induction of
IL-8 gene was partially
inhibited by both
TRAF6 and TRAF2
Li et al., American journal of physiology. Renal physiology 2002
:
TRAF6 , in turn,
activates SAPK/JNK and p38 MAPK phosphorylation, which in turn stimulates
IL-8 and MCP-1 production in these cells
Mason et al., Infect Immun 2004
:
TRAF6 dependent mitogen activated protein kinase activation differentially
regulates the production of
interleukin-12 by macrophages in response to Toxoplasma gondii
Frobøse et al., Mol Endocrinol 2006
:
Suppressor of cytokine Signaling-3
inhibits interleukin-1 signaling by targeting the
TRAF-6/TAK1 complex
Chung et al., J Biochem Mol Biol 2007
:
NF-kappaB activation by STP-C through the ubiquitinated
TRAF6 causes the increased production of
IL-8 , an inflammatory chemokine and the enhanced expression of costimulatory molecule ICAM, which might ultimately contribute cellular transformation by the exposure of HVS infected cells with inflammatory microenvironment and chronic activation