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LOX — TP53
Text-mined interactions from Literome
Torosyan et al., Cancer Res 2006
(Adenocarcinoma...) :
On the other hand, wild-type
p53 restored
5-LOX expression in DU145 to levels comparable to benign prostate epithelial cells ... Thus, ANXA7 and
p53 can distinctly
regulate LOX transcription that is potentially relevant to the AA-mediated cell growth control in tumor suppression
Bishayee et al., Acta Biochim Biophys Sin (Shanghai) 2013
(Neoplasms) :
Lastly, suppression of
5-LOX activity that reduces the cell proliferation activity also induces intrinsic mitochondrial apoptotic pathway in either
p53 dependent or independent manner