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IRF6 — IRF8
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
IRF6
—
IRF8
(physical association, affinity chromatography technology)
Li et al., Immunity 2011
-
IRef Biogrid Interaction:
IRF6
—
IRF8
(direct interaction, pull down)
Li et al., Immunity 2011
-
IRef Intact Interaction:
Complex of 19 proteins
(association, anti tag coimmunoprecipitation)
Li et al., Immunity 2011
-
IRef Intact Interaction:
IRF6
—
IRF8
(physical association, anti tag coimmunoprecipitation)
Li et al., Immunity 2011
-
IRef Intact Interaction:
Complex of IRF5-IRF6-IRF8-BNC2-BNC2-IRF6-IRF5-IRF8
(association, anti tag coimmunoprecipitation)
Li et al., Immunity 2011
Text-mined interactions from Literome
Kantakamalakul et al., J Immunol 1999
:
These findings extend in a significant way our understanding of the
regulation of
ICSBP by
LPS and IFN-gamma and provide important clues as to its role in macrophage activation
Wang et al., J Immunol 2000
:
Taken together, our results show that
ICSBP induced by
IFN-gamma/LPS , acts as a principal activator of IL-12p40 transcription in macrophages
Ohmori et al., J Leukoc Biol 2001
:
Activation of these STAT1 containing transcription factors was mediated by the intermediate induction of type I IFNs, since the
LPS induced IP-10,
IRF-1 , and iNOS mRNA expression was markedly reduced in macrophages from IFN-alpha/betaR-/- mice and blocked by cotreatment with antibodies against type I IFN
Hemmi et al., J Exp Med 2004
(Virus Diseases) :
Viral infection and stimulation with
lipopolysaccharide (LPS) or double stranded RNA ( dsRNA )
induce phosphorylation of
interferon ( IFN ) regulatory factor ( IRF)-3 and its translocation to the nucleus, thereby leading to the IFN-beta gene induction
Nencioni et al., Blood 2006
:
As a suitable mechanism for these effects, bortezomib was found to down-regulate MyD88, an essential adaptor for TLR signaling, and to relieve
LPS induced activation of NF-kappaB,
IRF-3 , and IRF-8 and of the MAP kinase pathway
Unlu et al., Mol Immunol 2007
:
Phosphorylation of
IRF8 in a pre associated complex with Spi-1/PU.1 and non phosphorylated Stat1 is
critical for
LPS induction of the IL1B gene
Abe et al., Arterioscler Thromb Vasc Biol 2008
(Inflammation...) :
Statins inhibited TLR4 mediated
activation of
interferon ( IFN ) regulatory factor ( IRF)3 by either
lipopolysaccharide (LPS) or palmitic acid, resulting in suppression of IFN-beta expression, but not that of NF-kappaB or JNK
Ogasawara et al., Journal of clinical biochemistry and nutrition 2011
:
Rebamipide reduced the expression of TBK1,
IRF3 and IRF7 mRNA
induced by
LPS/dsRNA , but not of NF-?B mRNA in colonic epithelial cells
Ke et al., Hepatology 2013
(Disease Models, Animal...) :
In contrast, knockdown of ß-catenin increased PTEN/TLR4 ( Toll-like receptor 4 ),
interferon regulatory factor-3 (IRF3), nuclear factor kappa B ( NF-?B ) activity, and proinflammatory cytokine programs in
response to
LPS stimulation
Faure et al., J Biol Chem 1999
:
The decrease of
LPS/IFN-gamma induced IRF-1 promoter activity,
IRF-1 synthesis, and IRF-1 activation, by PDTC, genistein, PD98059, and SB 203580, could explained in part the inhibition of the NOS-2 induction by these compounds