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MMP9 — SLC22A3

Text-mined interactions from Literome

Stallings-Mann et al., Cells Tissues Organs 2007 (Cell Transformation, Neoplastic) : We have identified the induction of Rac1b, an alternatively spliced variant of Rac1, as a key event in MMP induced EMT
Lee et al., Carcinogenesis 2008 (Breast Neoplasms...) : Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP dependent mechanism
Tan et al., Am J Pathol 2010 (Fibrosis...) : AMCM induced tubular cell EMT in C1.1 cells was inhibited by broad-spectrum MMP inhibitor ( GM6001 ), MMP-2/9 inhibitor, and in AMCM after MMP-9 removal by monoclonal Ab against MMP-9 ... AMCM induced EMT in primary tubular epithelial cells was inhibited by MMP-2/9 inhibitor ... MMP-9 induced tubular cell EMT in both C1.1 cells and primary tubular epithelial cells ... Furthermore, MMP-9 induced tubular cell EMT in C1.1 cells to an extent similar to transforming growth factor-beta
Asuthkar et al., Neuro Oncol 2011 (Cerebellar Neoplasms...) : Gadd45a sensitizes medulloblastoma cells to irradiation and suppresses MMP-9 mediated EMT ... Alternatively, inhibition of MMP-9 ( pM ) resulted in upregulation of Gadd45a and suppression of EMT
Tan et al., Lab Invest 2013 (Fibrosis...) : Early- and late-stage inhibition of MMP-9 in UUO mice significantly reduced tubular cell EMT and renal fibrosis ... A pro-fibrotic role of matrix metalloproteinase-9 (MMP-9) in tubular cell epithelial-mesenchymal transition (EMT) is well established in renal fibrosis ; however studies from our group and others have demonstrated some previously unrecognized complexity of MMP-9 that has been overlooked in renal fibrosis ... In summary, our result suggests that MMP-9 of both TEC and macrophage origin may directly or indirectly contribute to the pathogenesis of renal fibrosis via osteopontin cleavage, which, in turn further recruit macrophage and induce tubular cell EMT