◀ Back to GDNF

GDNF — PLG

Text-mined interactions from Literome

Sun et al., Thromb Res 2002 : In this report, the effect of ATF on single-chain uPA ( sc-uPA ) induced plasminogen activation was investigated ... It was shown that sc-uPA induced activation of Glu-plasminogen or Lys-plasminogen was significantly inhibited in the presence of ATF ... In contrast to sc-uPA induced Glu- or Lys-plasminogen activation, sc-uPA induced mini-plasminogen activation, sc-uPA activation by mini-plasmin and mini-plasminogen activation by tc-uPA were not affected by ATF ... These findings suggested that the inhibitory effects of ATF on sc-uPA activation by Lys-plasmin and Glu- or Lys-plasminogen activation by tc-uPA were related to the binding of ATF ( by its C-terminal Lys ( 135 ) and internal Lys/Arg residue ) with the kringle 1-4 of plasmin and plasminogen, respectively
Rockway et al., Curr Pharm Des 2002 : The N-terminal domain or ATF binds to a Urokinase receptor ( uPAR ) on the cell surface and the C-terminal serine protease domain, then, activates plasminogen to plasmin, beginning a cascade of events leading to the progression of cancer
Tanski et al., J Vasc Surg 2004 : Assays of DNA synthesis, cell proliferation, and migration were performed in response to sc-uPA, ATF , kringle, and CTF in the presence and absence of the plasmin inhibitors epsilon-aminocaproic acid ( EACA ) and aprotinin, the Galphai inhibitor pertussis toxin, and the mitogen activated protein kinase 1 ( the upstream regulator of the extracellular-signal regulated kinase [ ERK ] ) inhibitor PD98059
Lonka-Nevalaita et al., J Neurosci 2010 : In addition, we find that matrix metalloproteinases and plasmin that cleave pro-BDNF and pro-NGF are not responsible for the cleavage of pro-GDNF , whereas furin endoproteinase, PACE4, and proprotein convertases PC5A, PC5B, and PC7 can cleave pro-GDNF into mature GDNF