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AKT3 — IL10

Text-mined interactions from Literome

Pousset et al., Eur Cytokine Netw 2000 : Furthermore, anti-inflammatory cytokines such as IL-4 and IL-10 that block IL-1b induced NFkappaB activation also attenuate IL-1beta induced Akt phosphorylation, despite the fact that IL-4 and IL-10 in isolation induced Akt phosphorylation
Bhattacharyya et al., Blood 2004 : Furthermore, IL-10 blocked inducible Akt phosphorylation, and inhibitors of phosphatidylinositol 3-kinase (PI3K) effectively suppressed the activation of Akt , IKK, and NF-kappaB
Pengal et al., Mol Immunol 2006 : Lipopolysaccharide induced production of interleukin-10 is promoted by the serine/threonine kinase Akt ... In this study, we have examined the role of Akt in LPS induced IL-10 production ... Our experiments revealed that while Akt was activated under both conditions, the level of activation was significantly higher in cells stimulated with LPS and ICs, suggesting that Akt may be involved in IC-induced upregulation of IL-10 production ... Using several independent models we have then tested the notion that enhanced Akt activation may lead to enhanced LPS induced IL-10 production ... Over-expression of constitutively active Myr-Akt in the mouse macrophage cell line Raw 264.7 led to significant increase in IL-10 production in response to LPS ... In addition, down-regulation of Akt by siRNA resulted in a decrease in LPS induced IL-10 production ... Taken together, these data demonstrate that Akt plays a critical role in LPS induced production of IL-10
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Resveratrol inhibits high glucose induced PI3K/Akt/ERK dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Wegiel et al., J Biol Chem 2009 (Inflammation) : IL-10 regulation is dependent in part on the activation of Akt
Hatton et al., PloS one 2012 (Lymphoma, B-Cell) : Using small molecule inhibition and siRNA strategies in human B cell lines expressing a chimeric, signaling-inducible LMP1 protein, nerve growth factor receptor (NGFR)-LMP1, we show that NGFR-LMP1 utilizes Syk to activate PI3K/Akt signaling and induce IL-10 production
Wang et al., J Immunol 2013 (Inflammation) : Constitutive activation of Akt or inhibition of GSK3ß abrogated the capability of JAK3 inhibition to enhance proinflammatory cytokines and suppress IL-10 production