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GGA3 — TXN

Text-mined interactions from Literome

Dekigai et al., Free radical research 2001 : We recently reported that geranylgeranylacetone ( GGA ) , an anti-ulcer drug, induces TRX in rat hepatocytes ... In this study, we demonstrate that GGA promotes induction and secretion of TRX in rat gastric mucosal cells and human peripheral blood lymphocytes ( PBLs ) ... Western blotting and a sensitive sandwich ELISA showed that TRX was induced by GGA in the cell lysates and culture supernatants of rat gastric mucosal RGM-1 cells and human PBLs. LDH releasing assay showed that GGA protected rat gastric mucosal RGM-1 cells from ethanol induced cytotoxicity ... These results indicate that GGA promotes the induction and secretion of TRX in a variety of types of cells and suggest that induced or secreted TRX may play an important role in the cytoprotective action of GGA on gastric mucosal cells
Bai et al., Neurosci Lett 2002 (Parkinsonian Disorders) : Moreover, GGA induces expression of TRX and HSP70 and attenuates MPP ( + ) -induced toxicity in PC12 cells
Tanito et al., J Neurosci 2005 (Disease Models, Animal...) : In K-1034 cells, GGA ( 10 microM ) induced intracellular Trx , Hsp72, and extracellular Trx but not extracellular Hsp72. Extracellular Trx ( 0.75 nM ) attenuated H2O2 ( 200 microM ) -induced cell damage in 661W cells