Tinel et al., J Pharmacol Exp Ther 1999
:
Because IL-2 increases c-Myc in lymphocytes and because c-myc overexpression represses several genes, we postulated that the IL-2/IL-2R interaction may increase c-Myc and thereby down-regulate CYP in hepatocytes
Pandey et al., J Biol Chem 2000
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Finally, overexpression of wild type STAM2 led to an increase in IL-2 mediated induction of c-Myc promoter activation indicating that it potentiates cytokine receptor signaling
Shi et al., J Immunol 1997
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In the presence or the absence of serum, IL-2 and IL-3 induced expression of both c-Myc and Bax
Wang et al., Oncogene 1998
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Thus, c-Myc plays a fundamental role in the regulation of the expression of FasL, but not Fas and IL-2