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AKT2 — NTF4
Text-mined interactions from Literome
Roux et al., J Biol Chem 2001
:
The p75
neurotrophin receptor
activates Akt ( protein kinase B ) through a phosphatidylinositol 3-kinase dependent pathway
Perez-Pinera et al., Mol Cell Biochem 2007
(Adenocarcinoma...) :
Interestingly, inhibition of
neurotrophin receptor signaling using K252a
prevents Akt activation in response to NGF or BDNF, induces apoptotic cell death, and diminishes the ability of A549 cells to growth in soft agar
Ceni et al., J Cell Sci 2010
:
Neurons and PC12 cells lacking p75NTR display defects in
neurotrophin dependent
Akt activation
Je et al., Molecular brain 2011
(Synaptic Transmission) :
Previously, we demonstrated that the long-term synaptic modulation requires the endocytosis of
neurotrophin-receptor complex, the
activation of PI3K and
Akt , and mTOR mediated protein synthesis
Kommaddi et al., FASEB J 2011
:
We show that Trk induced ADAM17 phosphorylation and generation of the p75NTR ( ICD ) is required for
neurotrophin induced Erk and
Akt activation and for neurotrophin dependent survival signaling