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CXCR4 — ETS1
Text-mined interactions from Literome
Maroni et al., Carcinogenesis 2007
(Breast Neoplasms...) :
HGF
induces CXCR4 and CXCL12 mediated tumor invasion through
Ets1 and NF-kappaB ... In HGF treated MCF-7 cells, the DNA binding of
Ets1 activated by MAPK1/ERK1/2 transduction pathway as well as the DNA binding of NF-kappaB played a critical
role in
CXCR4 transcription and protein induction
Matteucci et al., Mol Cancer Res 2007
(Breast Neoplasms...) :
Thus, the
CXCR4 induction by HGF in MCF-7 cells
required NF-kappaB and
Ets1 activations, downstream of phosphoinositide-3-kinase/Akt, whereas in HGF treated MDA-MB231 cells, HDAC3 activation via c-Src probably caused a reduction of transcription factor activities, such as that of NF-kappaB