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AKT1 — FASLG
Text-mined interactions from Literome
Suhara et al., Mol Cell Biol 2002
:
Suppression of
Akt signaling
induces Fas ligand expression : involvement of caspase and Jun kinase activation in Akt mediated
Fas ligand regulation ... Suppression of
Akt signaling increased the activity of c-Jun N-terminal kinase, and transduction of dominant negative c-Jun
inhibited FasL induction under these conditions ... Diminished
Akt signaling promoted the cleavage of caspase 3, and both caspase 3 cleavage and
FasL induction were
inhibited by transduction of dominant negative caspase 9 or the caspase 8 inhibitor CrmA
Uriarte et al., Cell Death Differ 2005
:
In T lymphocytes, the role of
Akt in regulating
Fas/Fas ligand (FasL) mediated apoptotic signaling and death is not clearly understood
Lu et al., J Immunol 2006
:
In this study, we show that stimulation of the
Fas receptor by its ligand (FasL) induces rapid phosphorylation of
Akt/PKB and a parallel increase in cell apoptosis in epidermal Cl41 cells ... Treatment of the cells with pharmacological inhibitors of PI3K, wortmannin and 2- ( 4-morpholinyl ) -8-phenyl-4H-1-benzopyran-4-1 ( LY294002 ), similarly inhibits
FasL induced apoptosis and
Akt/PKB phosphorylation, indicating that PI3K is an upstream mediator of Akt/PKB and is involved in Fas mediated cell death ... Electron spin resonance studies show that FasL treatment induces rapid generation of reactive oxygen species, and inhibition of ROS by antioxidants effectively inhibits Akt/PKB signaling, suggesting that
FasL activation of
Akt/PKB is redox sensitive ... Electron spin resonance studies show that FasL treatment induces rapid generation of reactive oxygen species, and inhibition of ROS by antioxidants effectively inhibits Akt/PKB signaling, suggesting that
FasL activation of
Akt/PKB is redox sensitive
Selvendiran et al., J Biol Chem 2007
(Ovarian Neoplasms) :
Within 12 h, EF24 induced a membranous FasL expression, consistent with a substantial decrease in the Ser ( 473 ) and Thr ( 308 ) phosphorylation of
Akt , a known negative
regulator of
FasL transcription
Subramanyam et al., J Biol Chem 2010
:
Staurosporine, tumor necrosis factor-alpha, or a
Fas ligand inhibited both RVI and hypertonicity induced
Akt activation in a manner sensitive to a scavenger for reactive oxygen species ( ROS )
Lokeshwar et al., Cancer Res 2010
(Neoplasm Invasiveness...) :
4-MU
induced caspase-8, caspase-9, and caspase-3 activation, PARP cleavage, upregulation of
Fas-L , Fas, FADD and DR4, and downregulation of bcl-2, phosphorylated bad, bcl-XL, phosphorylated
Akt , phosphorylated IKB, phosphorylated ErbB2, and phosphorylated epidermal growth factor receptor
Casado-Zapico et al., J Pineal Res 2011
(Leukemia) :
The cytotoxic effect and the increase in Fas and
Fas L were
dependent on
Akt activation
Iyer et al., J Immunol 2011
:
We demonstrate using both human renal epithelial 293T cells and Jurkat T-lymphocyte cells that although
FasL activates both
Akt and NF-?B, Akt inhibits FasL dependent NF-?B activity in a reactive oxygen species dependent manner