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AHSA1 — IGF1
Text-mined interactions from Literome
Meares et al., FEBS Lett 2004
:
Furthermore, with
IGF-1 stimulation Hsp90 inhibition
increased p38 activation, produced additive activation of p90RSK, and slightly increased the duration of ERK1/2 activation
Jiang et al., J Cell Biochem 2006
(Hypertrophy) :
The Akt/GSK-3beta,
p38MAPK , and calcineurin pathways may
play an important role in
IGF-1 signaling, cell-cycle regulation, and matrix gene expression in mesangial cells leading to the development of diabetic glomerulopathy
Muñoz et al., Biochem Biophys Res Commun 2009
(Cardiomegaly) :
IGF-1 stimulated MEF2 dependent-gene transcription in a time dependent manner, as indicated by increased MEF2 promoter-driven reporter gene activity ;
IGF-1 also
induced p38-MAPK phosphorylation, while an inhibitor of p38-MAPK decreased both effects