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IL4 — SHC1
Pathways - manually collected, often from reviews:
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BioCarta il 4 signaling pathway:
IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4)
→
SHC (SHC1)
(modification, activates)
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NCI Pathway Database IL4-mediated signaling events:
GRB2 (GRB2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D-GRB2)
(modification, collaborate)
Wery et al., J Biol Chem 1996
Evidence: physical interaction
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NCI Pathway Database IL4-mediated signaling events:
GRB2 (GRB2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
(modification, collaborate)
Wery et al., J Biol Chem 1996
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D-GRB2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
(modification, collaborate)
Wery et al., J Biol Chem 1996
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
SHIP (INPP5D)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
(modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
→
SHC (SHC1)
(modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
SHC (SHC1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
Text-mined interactions from Literome
Soon et al., Mol Cell Biol 1999
:
IL-4 stimulation of the IGF-IR transfectants
resulted in enhanced tyrosine phosphorylation of
SHC , Erk2, and signal transducer and activator of transcription 6 ( STAT6 ) proteins
Day et al., Oncogene 2002
:
IL-4 did not
enhance HGF dependent tyrosine phosphorylation of c-Met or
Shc
Matsuguchi et al., J Biol Chem 1994
(Leukemia, Megakaryoblastic, Acute) :
Shc phosphorylation in myeloid cells is
regulated by granulocyte macrophage colony stimulating factor,
interleukin-3 , and steel factor and is constitutively increased by p210BCR/ABL