UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

CCR5 — CCR7

Pathways - manually collected, often from reviews:

Reactome Reaction: CCR5 → CCR7 (reaction) Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994

Text-mined interactions from Literome

Sato et al., J Immunol 2000 : Stimulation of mature DCs with TGF-beta 1 also enhanced TNF-alpha induced down-regulation of the expressions of CCR-1, CCR-3, CCR-5 , CCR-6, and CXCR-4, and chemotaxis to their respective ligands, while this stimulation suppressed TNF-alpha induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta
Moreno et al., Hepatology 2005 (Drug-Induced Liver Injury) : In conclusion, CCR5 deficiency exacerbates T-cell mediated hepatitis, and leads to increased levels of CCR5 ligands and a more pronounced liver mononuclear infiltrate, suggesting that CCR5 expression can modulate severity of immuno mediated liver injury
Pham et al., J Neuroimmunol 2012 (Brain Neoplasms...) : CCL5, CCR1 and CCR5 in murine glioblastoma : immune cell infiltration and survival rates are not dependent on individual expression of either CCR1 or CCR5