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SDC4 — TNF
Text-mined interactions from Literome
Zhang et al., J Biol Chem 1999
:
In vitro studies demonstrated that
TNF-alpha induced endothelial cell
syndecan-4 expression by both increasing syndecan-4 gene expression in an NF-kappaB dependent manner and by prolonging syndecan-4 mRNA half-life
Zhang et al., Nan Fang Yi Ke Da Xue Xue Bao 2007
:
[Tumor necrosis factor-alpha regulates the proliferation and
syndecan-4 expression of human umbilical vein endothelial-like cells cultured in vitro ] ... To investigate the
effects of
tumor necrosis factor-alpha(TNF-alpha) on
syndecan-4 protein expression and proliferation of cultured human umbilical vein endothelial-like cells ( HUVECs ) in vitro ... The expression of
syndecan-4 protein was significantly
enhanced by
TNF-alpha
Teixé et al., Mol Immunol 2008
:
However, cross linking of cell bound syndecan-2 or
syndecan-4 via immobilized antibodies
blocked proliferation and decreased
TNF production of T cells in the presence of optimal levels of anti-CD3
Zhang et al., Nan Fang Yi Ke Da Xue Xue Bao 2010
:
The expression of syndecan-4 protein in the VSMCs was significantly enhanced by 20 ng/ml TNF-alpha ( P < 0.01 ). Pravastatin alone did not affect the expression of syndecan-4 protein ( P > 0.05 ), but significantly inhibited
TNF-alpha induced enhancement of
syndecan-4 protein expression ( P < 0.01 )
Wang et al., J Biol Chem 2011
:
The goal of the investigation was to study if
TNF-a and IL-1ß
regulate syndecan-4 (SDC4) expression, and if SDC4 was responsible for promoting aggrecan degradation through controlling ADAMTS activity in nucleus pulposus cells of the intervertebral disc ... We conclude that in nucleus pulposus,
TNF-a and IL-1ß
regulate SDC4 expression, which plays a key role in pathogenesis of degenerative disc disease by promoting aggrecan degradation by ADAMTS-5
Tanino et al., Am J Respir Cell Mol Biol 2012
(Lung Injury...) :
Studies performed using BEAS-2B cells showed that pretreatment with heparin and
syndecan-4 decreased the expression of CXCL8 mRNA in
response to LPS and
TNF-a
Okuyama et al., J Biochem 2013
:
To elucidate these mechanisms in detail, we examined
syndecan-4 upregulation by
TNF-a in the endothelium-like EAhy926 cell