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NRAS — RASA1

Pathways - manually collected, often from reviews:

• KEGG Axon guidance: RASA1 → HRAS/KRAS/NRAS (protein-protein, inhibition)
• KEGG MAPK signaling pathway: RASA1 → HRAS/KRAS/MRAS/NRAS/RRAS/RRAS2 (protein-protein, inhibition)
  
• NCI Pathway Database IL2-mediated signaling events: RasGAP/Dok-R complex (RASA1-DOK2) → RAS family/GDP/Aiolos complex (HRAS_KRAS_HRAS_KRAS_NRAS-IKZF3) (modification, inhibits)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: RasGAP/Dok-R complex (RASA1-DOK2) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, inhibits)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: SOCS3/RasGAP complex (SOCS3-RASA1) → RAS family/GDP/Aiolos complex (HRAS_KRAS_HRAS_KRAS_NRAS-IKZF3) (modification, activates)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: SOCS3/RasGAP complex (SOCS3-RASA1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: SHC/RasGAP complex (SHC1-RASA1) → RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Li et al., Science 1992, Stephens et al., Neuron 1994
  Evidence: assay, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: SHC/RasGAP complex (SHC1-RASA1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Li et al., Science 1992, Stephens et al., Neuron 1994
  Evidence: assay, other species
• NCI Pathway Database Regulation of Ras family activation: RasGAP (RASA1) → NRAS/GDP complex (NRAS) (modification, activates) Trahey et al., Science 1987*
  Evidence: assay
• NCI Pathway Database Regulation of Ras family activation: RasGAP (RASA1) → NRAS/GTP complex (NRAS) (modification, activates) Trahey et al., Science 1987*
  Evidence: assay
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1) → RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Elowe et al., Mol Cell Biol 2001
  Evidence: genetic interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Elowe et al., Mol Cell Biol 2001
  Evidence: genetic interaction
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB) → RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
  Evidence: assay
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
  Evidence: assay
• Reactome Reaction: NRAS → RASA1 (indirect_complex)
• Reactome Reaction: NRAS → RASA1 (reaction) Nava et al., FEBS Lett 2000*, Shu et al., Mol Cell Biol 2002, Wu et al., Oncogene 2003*
• WikiPathways MAPK Signaling Pathway: RASA1 → MRAS/NRAS/KRAS (mim-inhibition)
• WikiPathways Rac1/Pak1/p38/MMP-2 pathway: RASA1 → HRAS/KRAS/NRAS (inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: RASA1 — NRAS (interaction, mapped from kegg_pathways)
• STRING interaction: NRAS — RASA1 (interaction, mapped from kegg_pathways)