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CIITA — STAT1
Pathways - manually collected, often from reviews:
-
FastForward regulation:
STAT1
→
CIITA
(transcriptional regulation, unknown)
Dong et al., J Immunol 1999*, Muhlethaler-Mottet et al., Immunity 1998*, Piskurich et al., Mol Cell Biol 1999*
Evidence: DNABINDING, PROMACTIVITY
-
FastForward regulation:
STAT1
→
CIITA
(transcriptional regulation, unknown)
Muhlethaler-Mottet et al., Immunity 1998*
Evidence: DNABINDING, PROMACTIVITY
-
KEGG Toxoplasmosis:
STAT1
→
CIITA
(protein-protein, activation)
-
KEGG Tuberculosis:
STAT1
→
CIITA
(gene expression, expression)
-
KEGG Influenza A:
STAT1
→
CIITA
(protein-protein, activation)
Text-mined interactions from Literome
Sakatsume et al., Kidney Int 2000
(Glomerulonephritis) :
Overexpression of
Stat1-mutant lacking 35 C-terminal amino acids strongly suppressed the IFN-gamma induced signal transduction and
inhibited the expression of MHC class II and
CIITA genes in mesangial cells
Barbaro et al., Eur J Immunol 2002
:
Block of
Stat-1 activation in macrophages phagocytosing bacteria
causes reduced transcription of
CIITA and consequent impaired antigen presentation
Xi et al., Mol Immunol 2003
:
The IFN-gamma activation of the
CIITA type IV promoter is
mediated by
STAT1 and IRF-1, which bind to the GAS and IRF-E of the promoter, respectively
Kwon et al., Mol Immunol 2007
:
In addition, although IRF-1 is a key transcription factor to activate the IFN-gamma inducible CIITA promoter, the effect of PKCdelta on
CIITA expression is
mediated primarily by serine phosphorylation of
Stat 1
D'Agostino et al., J Biol Chem 2012
:
STAT1 is an
activator of
CIITA , the class II transactivator for MHC II expression ; CIITA expression was concomitantly increased in IE-Cpr-null mice
Muhlethaler-Mottet et al., Immunity 1998
:
Activation of the MHC class II transactivator
CIITA by interferon-gamma
requires cooperative interaction between
Stat1 and USF-1
Piskurich et al., J Immunol 1998
:
A
role for
STAT1 in regulation of the
CIITA promoter is shown by the rescue of IFN-gamma induction by expression of STAT1 in STAT1-defective U3A cells
Lin et al., J Immunol 1998
:
Thus, thyroid hormone potentiation of IFN-gamma induced HLA-DR transcription is mediated by a cell membrane hormone binding site, enhanced activation of
STAT1alpha , and increased
CIITA induction