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NGF — NOS1

Text-mined interactions from Literome

Rife et al., Brain Res Mol Brain Res 2000 : Neuronal nitric oxide synthase (nNOS) is induced by nerve growth factor (NGF) in pheochromocytoma PC12 cells ... Thus, it is possible that activation of Ets and/or AP1 transcription factors by the Ras-Raf-MAP kinase cascade contributes to the NGF mediated induction of nNOS
Calza et al., Proc Natl Acad Sci U S A 2001 : NGF , either alone or associated with 6-OHDA, also induced a significant up-regulation of NADPH diaphorase, neuronal nitric oxide synthase , and vascular endothelial growth factor expression in scg neurons
Schonhoff et al., J Neurochem 2001 : We note that neither nNOS mRNA, nNOS protein nor NOS activity is induced by NGF treatment in cells that have been infected with a dominant negative Ras adenovirus ... Even though U0126 and PD98059 are both MEK inhibitors, we find that U0126, but not PD98059, blocks induction of nNOS protein and NOS activity in NGF treated PC12 cells ... Since the JNK pathway is not activated in NGF treated PC12 cells, we conclude that the Ras-ERK pathway and not the p38 or JNK pathway is required for nNOS induction in NGF treated PC12 cells
Gow et al., J Biol Chem 2002 : In cultured macrophages, SNO-protein levels increase upon cytokine induction of induced NOS (iNOS), and in PC12 cells, increased protein S-nitrosylation is linked to nerve growth factor induction of neuronal NOS (nNOS)
Kalisch et al., J Neurochem 2002 : NGF can regulate nitric oxide synthase (NOS) expression and nitric oxide ( NO ) can modulate NGF mediated neurotrophic responses ... NGF increased steady-state levels of mRNA and protein for both inducible and constitutive isozymes of NOS in PC12 cells, and led to enhanced NOS activity and NO production
Thippeswamy et al., Ann N Y Acad Sci 2002 : From culture studies, it was established that NGF negatively regulates nNOS synthesis in DRG neurons and that block of NO production leads to neuronal death
Kalisch et al., J Neurochem 2003 : Modulation of nerve growth factor induced activation of MAP kinase in PC12 cells by inhibitors of nitric oxide synthase ... Nerve growth factor (NGF) increases expression of nitric oxide synthase (NOS) isozymes leading to enhanced production of nitric oxide ( NO )
Thippeswamy et al., Brain Res Dev Brain Res 2005 : During late postnatal development, very few DRG neurons express nNOS ; however, axotomy or NGF deprivation of cultured DRG neurons induce nNOS and NOS blockade causes neuronal death
Binnington et al., J Neurochem 2007 : Nerve growth factor (NGF) can regulate nitric oxide synthase (NOS) expression and nitric oxide ( NO ) can modulate NGF mediated neurotrophic responses
Kawasaki et al., Nitric Oxide 2011 : Neuron growth factor (NGF) signaling in PC12 cell, which is derived from pheochromocytoma of rat adrenal medulla, induces expression of neuronal nitric oxide synthase (nNOS) and nitric oxide ( NO ) production
Peunova et al., Nature 1995 (Second Messenger Systems) : We show that NGF induces different forms of nitric oxide synthase (NOS) in neuronal cells, that nitric oxide ( NO ) acts as a cytostatic agent in these cells, that inhibition of NOS leads to reversal of NGF induced cytostasis and thereby prevents full differentiation, and that capacity of a mutant cell line to differentiate can be rescued by exogenous NO
Holtzman et al., Neurochem Res 1996 : We have previously shown that the neuronal isoform of nitric oxide synthase (NOS) is selectively expressed in a large fraction of trkA expressing cholinergic neurons in these brain regions in the adult rat, and that NGF induces the expression of neuronal-NOS in these cells
Chang et al., Neurochem Int 1997 : The nerve growth factor (NGF) induced neurite outgrowth and nitric oxide synthase expression appeared normal in PC12 cells treated with a sublethal dose of 25-OH-cholesterol
Lam et al., Proc Natl Acad Sci U S A 1998 : NGF significantly reduced NOS activity to 61 % of basal levels within 20 min of onset of delivery and maintained NOS activity at less than 50 % of baseline throughout 3 hr of delivery
Phung et al., Brain Res Mol Brain Res 1999 : Thus, we concluded that the NO required for PC12 cell differentiation, in response to NGF , is produced by nNOS