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NFKB1 — NQO1
Pathways - manually collected, often from reviews:
-
WikiPathways Oxidative Stress:
NFKB1/SP1/NFE2L2
→
HMOX1/GPX1/GPX3/NQO1/UGT1A6
(activation)
Text-mined interactions from Literome
Korashy et al., J Biochem Mol Toxicol 2008
(MAP Kinase Signaling System) :
In the current study, we examined the
role of redox-sensitive transcription factors,
NF-kappaB and AP-1 signaling pathways in the modulation of
Nqo1 by heavy metals ... These results clearly demonstrate that activation of
NF-kappaB negatively
regulates the expression of
Nqo1 by heavy metals, whereas AP-1 signaling pathways differentially modulates the heavy metal mediated effects
Dong et al., Exp Mol Med 2010
(Lung Neoplasms) :
It has been shown that
NQO1 is also
essential for the TNF induced activation of
NF-kappaB and that beta-lap suppresses the TNF induced NF-kappaB activation ... Irradiation with 4 Gy markedly increased the DNA binding activity of NF-kappaB in A549 cells, but not in the shNQO1 A549 cells, thus demonstrating that
NQO1 plays a pivotal role in irradiation induced
NF-kappaB activation ... It is concluded that beta-lap suppresses the radiation induced activation of NF-kappaB by interrupting the
involvement of
NQO1 in the activation of
NF-kappaB , thereby inhibiting the transcription of survival signals
Hoshino et al., J Med Chem 2010
:
Five resveratrol sulfate metabolites were synthesized and assessed for activities known to be mediated by resveratrol : inhibition of tumor necrosis factor (TNF) alpha induced
NFkappaB activity, cylcooxygenases ( COX-1 and COX-2 ), aromatase, nitric oxide production in endotoxin stimulated macrophages, proliferation of KB or MCF7 cells,
induction of
quinone reductase 1 (QR1) , accumulation in the sub-G ( 1 ) phase of the cell cycle, and quenching of 2,2-diphenyl-1-picrylhydrazyl ( DPPH ) free radical ... Two metabolites showed activity in these assays ; the 3-sulfate exhibited
QR1 induction, DPPH free radical scavenging, and COX-1 and COX-2 inhibitory activities and the 4'-sulfate
inhibited NFkappaB induction, as well as COX-1 and COX-2 activities