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SRC — STAT1

Pathways - manually collected, often from reviews:

• Reactome Reaction: SRC → STAT1 (indirect_complex) Brizzi et al., J Biol Chem 1999, Ning et al., Oncogene 2001, Deberry et al., Biochem J 1997
• Reactome Reaction: SRC → STAT1 (reaction) Brizzi et al., J Biol Chem 1999, Ning et al., Oncogene 2001, Deberry et al., Biochem J 1997

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SRC — STAT1 (physical association, affinity chromatography technology) Chang et al., Mol Pharmacol 2004*
• IRef Biogrid Interaction: SRC — STAT1 (physical association, affinity chromatography technology) Olayioye et al., J Biol Chem 1999
• IRef Biogrid Interaction: SRC — STAT1 (physical association, affinity chromatography technology) Cirri et al., Biochem Biophys Res Commun 1997
• IRef Hprd Interaction: SRC — STAT1 (in vivo) Cirri et al., Biochem Biophys Res Commun 1997
• IRef Ophid Interaction: SRC — STAT1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: SRC — STAT1 (aggregation, confirmational text mining) Cirri et al., Biochem Biophys Res Commun 1997

Text-mined interactions from Literome

Vasilenko et al., Tsitologiia 2001 : Using a pharmacological inhibitor of Src kinases CGP77675 and cells with knockout c-src, it was shown that Src activated STAT1 upon stimulation by both epidermal growth factor and hypersomatic shock
Burova et al., Tsitologiia 2003 : In contrast, H2O2 mediated activation of STAT1 requires only Src kinase activity
Chang et al., Mol Pharmacol 2004 : One is the JAK1/2 dependent PLC-gamma pathway inducing the activations of PKCalpha, c-Src , and STAT1, and the other is the direct activation of STAT1 by JAK1/2
Vasilenko et al., Tsitologiia 2004 : STAT1 and STAT3 activation upon EGF is blocked by both nocodazole and Src-kinase family inhibitor ... IFNalpha induced activation of STAT1 was not inhibited by either nocodazole or Src-kinase inhibitor
Krejci et al., J Cell Sci 2008 : Moreover, addition of active STAT1 and STAT3 to the FGF signal, by means of cytokine treatment, SRC mediated STAT activation or expression of constitutively active STAT mutants does not sensitize RCS chondrocytes to FGF mediated growth arrest
Cirri et al., Biochem Biophys Res Commun 1997 : c-Src activates both STAT1 and STAT3 in PDGF stimulated NIH3T3 cells ... Taken together, these data suggest that c-Src is involved in activation of both STAT1 and 3 in PDGF signal transduction