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CYP19A1 — PRL
Text-mined interactions from Literome
Ryde et al., Cancer Res 1992
(Breast Neoplasms) :
Aromatase activity in T47D cells was
stimulated by transforming growth factor alpha, epidermal growth factor, platelet derived growth factor,
prolactin , dexamethasone, and cortisol individually and PDA and ( Bu ) 2cAMP in combination
De Coster et al., Curr Opin Drug Discov Devel 2000
:
Using three examples : ( i ) thyroid hyperplasia ; ( ii )
prolactin induced mammary gland hyperplasia in rats ; and ( iii )
aromatase inhibition, the usefulness and limitation of serum endocrine analyses in classical toxicological studies, the need for specific mechanistic studies and the major importance of integration between pharmacodynamic, pharmacokinetic and toxicological data will be discussed
Feuermann et al., International journal of endocrinology 2009
:
Also,
prolactin affected
aromatase mRNA expression in the bovine mammary fat and we demonstrated that leptin and prolactin can affect cholesterol secretion from explants in culture to the medium
Hummel et al., Fertil Steril 1990
(Hyperprolactinemia) :
Prolactin (PRL) has been shown to have inhibitory effect on follicle stimulating hormone
induced aromatase activity and estrogen biosynthesis in human granulosa cells cultured in vitro
Kawagoe et al., Gynecol Obstet Invest 1989
:
To assess the
role of
prolactin (PRL) in the puberty onset and the ovarian
aromatase activity, hyper- and hypoprolactinemic conditions were induced by treating chronically prepubertal female rats with PRL and bromocriptine, respectively
Papadopoulos et al., Andrologie 1986
:
In vitro
effects of
prolactin and dexamethasone on rat Leydig cell
aromatase activity
Tseng et al., Endocrinology 1987
:
On the other hand, human CG, epidermal growth factor, human
PRL , and insulin did not
increase the
aromatase activity in the presence or absence of MPA and E2 studied in a limited number of specimens
Munabi et al., Horm Metab Res 1985
:
To investigate whether hyperprolactinemia directly affects rat testicular steroidogenesis, we examined the
effects of
prolactin (PRL) on microsomal 3 beta-hydroxysteroid dehydrogenase ( 3 beta-HSD ) 17-hydroxylase ( 17-OH ), 17,20-desmolase ( 17,20-D ), 17-ketosteroid reductase ( 17-KSR ) and
aromatase enzyme activities
Advis et al., Biol Reprod 1983
:
The increased E2 response was not due to a direct
effect of
Prl on ovarian
aromatase activity since administration of oPrl to hypophysectomized rats failed to enhance the formation of E2 from testosterone ( T ) in vitro, and inhibited the increase in the enzyme activity induced by FSH ... It is suggested that : a ) in intact prepubertal rats Prl increases the E2 response of the ovary to gonadotropins by facilitating follicular development rather than by a direct action on aromatase activity, and b ) when follicular development is stimulated by FSH, an inhibitory
effect of
Prl on
aromatase activity becomes apparent
Hu et al., Sheng Li Xue Bao 1995
:
However, the
aromatase activity induced by FSH and hCG was remarkably
inhibited by the presence of
PRL