Gene interactions and pathways from curated databases and text-mining

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IL1A — PTX4

Text-mined interactions from Literome

Marcinkiewicz et al., Immunopharmacology 2000 : PTX also affects the production of other cytokines such as IL-1 , IL-6, IL-10, IL-12, and IFN-gamma
Banfi et al., J Pharmacol Exp Ther 2004 (Brain Ischemia...) : PTX treatment did induce a greater increase of serum tumor necrosis factor-alpha (TNF-alpha), but not of interleukin (IL)-1beta and IL-6 induced by in vivo administration of lipopolysaccharide (LPS), which suggests a protective role for TNF-alpha
Nishida et al., J Biol Chem 2010 : Microarray analysis revealed that PTX increases the induction of interleukin (IL)-1beta among cytokines
Okuda et al., Immunopharmacology 1996 (Encephalomyelitis, Autoimmune, Experimental) : Semiquantitative reverse transcriptase-polymerase chain reaction analysis revealed that PTX at this dose reduced the mRNA levels for tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 in peripheral blood mononuclear cells ( PBMC ) of mice with EAE
Redondo et al., Exp Dermatol 1997 : PTX and BC reduced TPA induced IL-1 alpha and beta expression
Polentarutti et al., Eur J Immunol 1998 : PTX3 is a prototypic long pentraxin expressed by various cell types, most prominently monocytes and endothelial cells, in response to interleukin-1 (IL-1) , tumor necrosis factor (TNF) and bacterial products
Schratzberger et al., Immunopharmacology 1999 : In the present study, we investigated the effects of the anti-inflammatory drug pentoxifylline ( PTX ) on activation of endothelial cells for enhanced adhesion and transmigration of neutrophils by lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1) and granulocyte colony stimulating factor ( G-CSF )