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IL1B — SMAD3

Text-mined interactions from Literome

Benus et al., Mol Biol Cell 2005 : IL-1beta and its downstream mediator TAK1 inhibit SMAD3 mediated TGFbeta target gene activation, whereas SMAD3 nuclear translocation and DNA binding in response to TGFbeta are not affected
Baugé et al., Arthritis Rheum 2007 : IL-1beta down-regulated TGFbetaRII expression at both the protein and mRNA levels and led to inhibition of the TGFbeta1 induced gene expression and Smad2/3 phosphorylation
Datta De et al., PloS one 2011 : IL1B inhibited phosphorylation of Smad 3 and subsequently interfered with nuclear translocation of the positive Smad complex, thus occluding it off the gastrin promoter