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CDK6 — MYLIP

Text-mined interactions from Literome

Lee et al., Pancreatology 2009 (Pancreatic Neoplasms) : Epigenetic silencing of MicroRNA miR-107 regulates cyclin dependent kinase 6 expression in pancreatic cancer
Agirre et al., Cancer Res 2009 (Disease Models, Animal...) : Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia ... Epigenetic down-regulation of miR-124a induced an up-regulation of its target, CDK6 , and phosphorylation of retinoblastoma ( Rb ) and contributed to the abnormal proliferation of ALL cells both in vitro and in vivo
Li et al., Cancer Res 2009 (Brain Neoplasms...) : Transfection of miR-34a down-regulated c-Met in human glioma and medulloblastoma cells and Notch-1, Notch-2, and CDK6 protein expressions in glioma cells
Lu et al., Cancer Res 2011 (Nasopharyngeal Neoplasms) : Mechanistic investigations revealed that miR-26a suppressed the expression of c-myc, the cyclin D3 and E2, and the cyclin dependent kinase CDK4 and CDK6 while enhancing the expression of CDK inhibitors p14(ARF) and p21 ( CIP1 ) in an EZH2 dependent manner
Feng et al., Med Oncol 2012 (Neoplasm Invasiveness...) : miR-107 could significantly suppress CDK6 3 ' UTR luciferase reporter activity, and this effect was not detectable when the putative 3 ' UTR target site was mutated ... Consistent with the results of the reporter assay, ectopic expression of miR-107 reduced both mRNA and protein expression levels of CDK6 , inhibited proliferation, induced G1 cell cycle arrest, and blocked invasion of the gastric cancer cells
Ma et al., Beijing Da Xue Xue Bao 2011 (Ovarian Neoplasms) : Ectopic expression of miR-449b and miR-34c resulted in lowered adhesion activities by 28 % -34 %, and in cell cycle arrests with increased cell number of 15.62 % and 15.71 % in G1 and with decreased cell number of 15.96 % and 16.56 % in S. Cell cycle related proteins CDK6 and CDC25A were down-regulated ... miR-449b and miR-34c resulted in cell cycle arrests and down-regulation of CDK6 , CDC25A and CyclinA in high malignant ovarian cancer cell line SKOV3-ipl
Ponomarev et al., BMC research notes 2011 : We found that ectopic overexpression of miR-124 resulted in the downregulation of CDK6 , decreased cellular proliferation, and induced cellular morphological changes
Zhu et al., Nucleic Acids Res 2012 (Neoplasms) : Further investigation disclosed that miR-26a/b directly suppressed the expression of CDK6 and cyclin E1, which resulted in reduced phosphorylation of pRb
Maki et al., Anticancer Res 2012 (Mesothelioma...) : miR-34b/c inhibited expression of cyclin-D1, cyclin dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly ( ADP-ribose ) polymerase ( cPARP ) and cleaved caspase-3 after irradiation ... miR-34b/c inhibited expression of cyclin-D1, cyclin dependent kinase 4/6 , B-cell lymphoma-2 (BCL-2) and increased cleaved poly ( ADP-ribose ) polymerase ( cPARP ) and cleaved caspase-3 after irradiation
Silber et al., Neuro Oncol 2013 (Cerebellar Neoplasms...) : MicroRNA (miR)-124 inhibits expression of CDK6 and prevents proliferation of glioblastoma and medulloblastoma cells in vitro
Deng et al., Gene 2013 (Stomach Neoplasms) : Expression of cyclin dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 , respectively
Giglio et al., J Cell Physiol 2013 : In this report we describe that miR-24 directly targets p27 ( Kip1 ) and p16(Ink4a) in primary keratinocyte and in different cancer derived cell lines promoting their proliferation, suggesting that miR-24 is involved in cyclin dependent kinase inhibitors post-transcriptional regulation and that upregulation of miR-24 may play a role in carcinogenesis