Gene interactions and pathways from curated databases and text-mining

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PTK2 — PTPRC

Text-mined interactions from Literome

Yu et al., Clin Exp Immunol 2002 : However, only anti-CD45RO suppressed Src family protein tyrosine kinase p56lck expression in the cells
He et al., Eur J Immunol 2002 (Calcium Signaling) : CD45 , a transmembrane protein tyrosine phosphatase (PTP), can either positively or negatively regulate Src-family protein tyrosine kinase ( PTK ) activity in vivo
Koretzky et al., J Immunol 1992 (Second Messenger Systems) : These results support the role of CD45 tyrosine phosphatase activity in regulating the TCR activated PTK
Dawes et al., J Med Genet 2006 (Hepatitis C) : C77G individuals showed an increased proportion of primed CD45RA and effector memory CD8 T cells and more rapid activation of the lymphocyte specific protein tyrosine kinase ( Lck ) following CD3 stimulation
Koretzky et al., J Biol Chem 1993 : These data suggest strongly that lck is the relevant protein tyrosine kinase found in CD45 immunoprecipitates in the Jurkat T cell line and that there is an additional association between CD45 and p34 which does not require the presence of the protein tyrosine kinase
Péléraux et al., Virology 1998 : Our data show that cells respond to 13B8.2 postinfection treatment regardless of CD45 expression, indicating that neither CD45 nor PTK regulated by CD45 are implicated in the mechanism of action of this antibody