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ECM1 — ERVK-6

Text-mined interactions from Literome

Khan et al., J Biol Chem 2004 (MAP Kinase Signaling System) : The addition of PGE ( 2 ) to macrophage cultures stimulates their expression of both urokinase-type plasminogen activator and MMP-9, and the selective COX-2 inhibitor NS-398 blocks ECM induced proteinase expression
Pavlovic et al., J Biol Chem 2006 (MAP Kinase Signaling System) : We previously reported that macrophage engagement of vascular extracellular matrix ( ECM ) triggers proteinase expression through a MAPKerk1/2 dependent increase in COX-2 expression and PGE2 synthesis ... When compared with COX-2 silencing by small interfering RNA or inhibition by celecoxib, the EP4 antagonist was as effective in inhibiting ECM induced proteinase expression ... Thus, COX-2 dependent ECM induced proteinase expression is effectively blocked by selective inhibition of EP4, a member of the PGE2 family of receptors