Gene interactions and pathways from curated databases and text-mining

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IL2 — SYK

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Kawakami et al., Proc Natl Acad Sci U S A 2000 : Syk/Btk mediated PKCbetaI regulation is involved in transcriptional activation of the IL-2 and tumor necrosis factor alpha genes through the JNK pathway induced by FcepsilonRI stimulation
Slack et al., Eur J Immunol 2007 : Syk dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan
Minami et al., Immunity 1995 : cDNA expression studies further revealed that this association is critical for the IL-2 induced activation of Syk PTK, which occurs primarily via the serine-rich region of the IL-2R beta chain, which is essential for proliferative signal transmission
Qin et al., FEBS Lett 1994 : Interleukin 2 mediates p72syk activation in peripheral blood lymphocytes ... The ability of interleukin 2 (IL-2) to stimulate p72syk activity in intact porcine peripheral blood lymphocytes was examined ... We demonstrated that IL-2 activated p72syk in a time- and dose dependent manner, for which its peak time and maximum responsive dose were 5 min and 100 U/ml, respectively