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IL2 — PRKCB
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Long et al., J Immunol 2001
:
This study demonstrates that
PKCbeta is not
necessary for transcription of the
IL-2 gene or translation of mRNA to protein, but that expression of this PKC isoform is critical to the export of IL-2 molecules from T cells
Thuille et al., Mol Immunol 2004
:
Additionally, a critical
role of
PKCbeta in TCR/CD28 stimulated regulation of IL-2 gene transcription but also exocytotic
IL-2 secretion was observed in leukemic T cell lines ... These findings suggest that
PKCbeta plays a redundant role in TCR induced regulation of
IL-2 cytokine production and T cell proliferation
Kelleher et al., FEBS Lett 1992
:
These data suggest that
PKC-beta may be a regulatory enzyme for proliferation and
stimulated interleukin-2 secretion in HuT 78 cells
Cervino et al., J Biol Regul Homeost Agents 2010
(Lymphoma, T-Cell...) :
Our results revealed new PKCbeta functions, affecting CD69 expression and IL-8 production, and support the
requirement for
PKCbeta in IL-2 secretion/transcription and
IL-2R regulation
Koretzky et al., J Immunol 1989
(Leukemia, T-Cell) :
Our results indicate that
PKC-beta , which is expressed in some T cells, is not
necessary for PMA induced CD3 or CD4 internalization,
IL-2 production, or acquisition of the p55 chain of the IL-2 receptor
Szamel et al., Eur J Immunol 1993
:
Thus, inhibition of the activation and translocation of
PKC-beta by CsA may
result in inhibition of
IL-2 gene expression in human lymphocytes
Hassan et al., Immunology 1997
:
In this study, the
role of
PKC-beta in intracellular accumulation of
IL-2 was investigated using specific inhibitors ... Using the specific inhibitors, Go6976 and GF109203X, the findings in this study suggest that activation and translocation of
PKC-beta is
critical for accumulation of intracellular
IL-2
Szamel et al., J Immunol 1998
:
Neutralization of PKC-alpha and -theta resulted in the complete inhibition of IL-2R expression, whereas
anti-PKC-beta , -delta, and -epsilon Abs
inhibited IL-2 synthesis