Gene interactions and pathways from curated databases and text-mining

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CXCL12 — VAV1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Ticchioni et al., Blood 2002 : Furthermore, CXCL12 induced time dependent phosphorylation of ZAP-70, Vav1 , and extracellular signal regulated kinases ( ERKs ) ; the latter were reduced in the absence of functional ZAP-70 ... Furthermore, CXCL12 induced time dependent phosphorylation of ZAP-70, Vav1 , and extracellular signal regulated kinases ( ERKs ) ; the latter were reduced in the absence of functional ZAP-70
Okabe et al., Blood 2005 : SDF-1alpha/CXCL12 induced the tyrosine phosphorylation of Pyk2 and the association of Pyk2 with zeta chain associated protein-70 kilodaltons ( Zap-70 ) and Vav
García-Bernal et al., Mol Biol Cell 2005 : CXCL12 activates the GTPase Rac, as well as Vav1 , a guanine-nucleotide exchange factor for Rac, concomitant with up-regulation of alpha4beta1 dependent adhesion ... Adhesions in flow chambers and soluble binding assays using these transfectants indicated that initial ligand binding and adhesion strengthening mediated by alpha4beta1 were dependent on Vav1 and Rac activation by CXCL12
Bartolomé et al., Cancer Res 2006 (Melanoma...) : We show that melanoma cells express Vav1 and Vav2, which are activated by CXCL12 involving Jak activity ... Blocking Vav expression by RNA interference results in impaired activation of Rac and Rho by CXCL12 and in a remarkable inhibition of CXCL12 promoted invasion