◀ Back to CXCL12
CXCL12 — VAV1
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
VAV1
→
CXCL12
(increases)
Evidence: timulation of human T cells with CXCL12 causes VAV1 to become phosphorylated and to relocalize to the leading edge of the cell108.
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NCI Pathway Database CXCR4-mediated signaling events:
RAC1-CDC42/GDP complex (RAC1_CDC42)
→
SDF1/CXCR4/VAV1 complex (CXCL12-CXCR4-VAV1)
(modification, collaborate)
Vicente-Manzanares et al., Blood 2005, García-Bernal et al., Mol Biol Cell 2005
Evidence: mutant phenotype, assay
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NCI Pathway Database CXCR4-mediated signaling events:
SDF1/CXCR4/VAV1 complex (CXCL12-CXCR4-VAV1)
→
None
(modification, activates)
Vicente-Manzanares et al., Blood 2005, García-Bernal et al., Mol Biol Cell 2005
Evidence: mutant phenotype, assay
-
NCI Pathway Database CXCR4-mediated signaling events:
SDF1/CXCR4/VAV1 complex (CXCL12-CXCR4-VAV1)
→
G beta/gamma complex (GNB1-GNG2)
(modification, activates)
Vicente-Manzanares et al., Blood 2005, García-Bernal et al., Mol Biol Cell 2005
Evidence: mutant phenotype, assay
-
NCI Pathway Database CXCR4-mediated signaling events:
SDF1/CXCR4/VAV1 complex (CXCL12-CXCR4-VAV1)
→
None
(modification, activates)
Vicente-Manzanares et al., Blood 2005, García-Bernal et al., Mol Biol Cell 2005
Evidence: mutant phenotype, assay
-
NCI Pathway Database CXCR4-mediated signaling events:
VAV1 (VAV1)
→
SDF1/CXCR4 complex (CXCL12-CXCR4)
(modification, collaborate)
Vicente-Manzanares et al., Blood 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database CXCR4-mediated signaling events:
VAV1 (VAV1)
→
SDF1/CXCR4/VAV1 complex (CXCL12-CXCR4-VAV1)
(modification, collaborate)
Vicente-Manzanares et al., Blood 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database CXCR4-mediated signaling events:
SDF1/CXCR4 complex (CXCL12-CXCR4)
→
SDF1/CXCR4/VAV1 complex (CXCL12-CXCR4-VAV1)
(modification, collaborate)
Vicente-Manzanares et al., Blood 2005
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Ticchioni et al., Blood 2002
:
Furthermore,
CXCL12 induced time dependent phosphorylation of ZAP-70,
Vav1 , and extracellular signal regulated kinases ( ERKs ) ; the latter were reduced in the absence of functional ZAP-70 ... Furthermore,
CXCL12 induced time dependent phosphorylation of ZAP-70,
Vav1 , and extracellular signal regulated kinases ( ERKs ) ; the latter were reduced in the absence of functional ZAP-70
Okabe et al., Blood 2005
:
SDF-1alpha/CXCL12 induced the tyrosine phosphorylation of Pyk2 and the association of Pyk2 with zeta chain associated protein-70 kilodaltons ( Zap-70 ) and
Vav
García-Bernal et al., Mol Biol Cell 2005
:
CXCL12 activates the GTPase Rac, as well as
Vav1 , a guanine-nucleotide exchange factor for Rac, concomitant with up-regulation of alpha4beta1 dependent adhesion ... Adhesions in flow chambers and soluble binding assays using these transfectants indicated that initial ligand binding and adhesion strengthening mediated by alpha4beta1 were dependent on
Vav1 and Rac
activation by
CXCL12
Bartolomé et al., Cancer Res 2006
(Melanoma...) :
We show that melanoma cells express
Vav1 and Vav2, which are
activated by
CXCL12 involving Jak activity ... Blocking
Vav expression by RNA interference
results in impaired activation of Rac and Rho by
CXCL12 and in a remarkable inhibition of CXCL12 promoted invasion