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NOS2 — TYK2

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL12-mediated signaling events: IL12Rbeta1/TYK2 complex (IL12RB1-TYK2) → NOS2 (NOS2) (modification, collaborate) Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database IL12-mediated signaling events: NOS2 (NOS2) → IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) (modification, activates)
  Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
  Evidence: mutant phenotype, assay, other species

Text-mined interactions from Literome

Diefenbach et al., Science 1999 (Leishmaniasis, Cutaneous) : Activation of Tyk2 in NK cells by IFN-alpha/beta also required NOS2
Painz et al., Immunobiology 2007 : Our data suggest that iNOS is induced through IFNAR1 and TYK2 in Mac3 positive cells which are the main source of iNOS in spleen and lung