Gene interactions and pathways from curated databases and text-mining

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NEDD4 — SIRT1

Text-mined interactions from Literome

Liu et al., Cell Death Differ 2013 : Consistent with this finding, SIRT2 repressed NEDD4 gene expression by directly binding to the NEDD4 gene core promoter and deacetylating histone H4 lysine 16
Han et al., Protein & cell 2013 : Upregulation of SIRT1 by 17ß-estradiol depends on ubiquitin-proteasome degradation of PPAR-? mediated by NEDD4-1