Gene interactions and pathways from curated databases and text-mining

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AGTR1 — MMP2

Text-mined interactions from Literome

Li et al., Yao Xue Xue Bao 2003 (Ear Diseases...) : Gelatin zymography results showed that MMP-9 expression in U937 cells increased significantly after exposed to PMA at 1 x 10 ( -8 ) mol.L-1 ( P < 0.001 ) ; MMP-9 expression induced with phorbol myristate acetate ( PMA ) was inhibited by dexamethasone at 1 x 10 ( -9 ), 1 x 10 ( -7 ) and 1 x 10 ( -5 ) mol.L-1, indomethacin at 1 x 10 ( -6 ) and 1 x 10 ( -5 ) mol.L-1 and resveratrol at 1 x 10 ( -6 ) and 1 x 10 ( -5 ) mol.L-1
Brassard et al., Hypertension 2005 : Concomitant AT1/AT2 blockade prevented growth, reduced collagen type I and elastin deposition but increased vascular stiffness, fibronectin, and MMP-2 activity
Huang et al., Dig Dis Sci 2008 (Stomach Neoplasms) : Angiotensin II type 1 receptor expression in human gastric cancer and induces MMP2 and MMP9 expression in MKN-28 cells ... In this study, we investigated the expression of angiotensin II type1 receptor (AT1R) in gastric cancer and the effects of Ang II on the expression of MMP2 and MMP9 in the human gastric cancer cell line MKN-28 cells
Akhavan et al., Pak J Biol Sci 2011 (Melanoma) : AT1 receptors activation enhances the expression of MMP-2, MMP-13 and VEGF but not MMP-9 in B16F10 melanoma cells
Piao et al., Chem Biol Interact 2013 (Necrosis) : In the present study, caspase dependent apoptosis was induced by SHK treatment at 1µM after 6h in U937 cells, with increase in DNA fragmentation, generation of intracellular reactive oxygen species ( ROS ), fraction of cells with low mitochondrial membrane potential ( MMP ) , and in the expression of BH3 only proteins Noxa and tBid