◀ Back to MAPK14
AGTR1 — MAPK14
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Touyz et al., J Hypertens 2001
(Hypertension) :
Differential
activation of extracellular signal regulated protein kinase 1/2 and p38
mitogen activated-protein kinase by
AT1 receptors in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats
Bobrovskaya et al., J Neurochem 2001
(MAP Kinase Signaling System) :
Angiotensin II ( AII, 100 nM ) stimulation of bovine adrenal chromaffin cells ( BACCs ) produced
angiotensin II receptor subtype 1 (AT1) mediated increases in extracellular regulated protein kinase 1/2 ( ERK1/2 ) and stress activated
p38MAPK ( p38 kinase ) phosphorylation over a period of 10 min. ERK1/2 and p38 kinase phosphorylation preceded Ser31 phosphorylation on tyrosine hydroxylase (TOH)
Hines et al., Biochem Pharmacol 2003
:
The failure of a protein kinase C inhibitor to block
AT(1) receptor
activation of
p42/44(MAPK) further corroborated evidence that the receptor 's activation of p42/44(MAPK) is largely independent of the G ( q ) /PLC-beta/PKC pathway ... Taken together, the experimental evidence strongly suggests that the mechanism whereby the
AT(1) receptor
activates p42/44(MAPK) is fundamentally different from that for PLC-beta, even at the level of the receptor itself
Kumar et al., J Cardiovasc Pharmacol Ther 2003
(Disease Models, Animal...) :
Our aim was to assess the
effect of selective
AT1 and AT2 receptor blockade with losartan and PD123,319, respectively, on
MAPK expression after ischemia-reperfusion in isolated working rat hearts
Nishiyama et al., Kidney Int 2004
(Hypertension, Renal...) :
Here, we examined the
effect of
angiotensin II type 1 receptor (AT1) receptor blockade on renal injury and
MAPK activity in Dahl salt-sensitive ( DS ) rats
Godeny et al., Am J Physiol Cell Physiol 2006
:
High-affinity binding of angiotensin II (ANG II) to the ANG II type 1 receptor (
AT(1)R )
results in the activation of ERK1/2 mitogen activated protein kinases (
MAPK )
Guo et al., Peptides 2006
(MAP Kinase Signaling System) :
Furthermore,
AT(1) is
required for
p38MAPK phosphorylation induced by Ang II
Wei et al., Hypertension 2008
(Disease Models, Animal...) :
These data indicate that
MAPK plays an important role in the upregulation of
AT(1)-R in the rat forebrain in HF and suggest that Ang II upregulates its own receptor by this mechanism
Silva et al., J Renin Angiotensin Aldosterone Syst 2010
:
AT1 receptor and NAD ( P ) H oxidase
mediate angiotensin II-stimulated antioxidant enzymes and
mitogen activated protein kinase activity in the rat hypothalamus
Zhang et al., Am J Physiol Heart Circ Physiol 2012
(MAP Kinase Signaling System) :
Aldosterone induced brain
MAPK signaling and sympathetic excitation are
angiotensin II type-1 receptor dependent ... These data suggest that aldosterone induced sympathetic excitation depends upon that
AT(1)R induced
MAPK signaling in the brain
Sörensson et al., Biochem J 2012
:
Further characterization of one of these new substrates confirmed that
At1g80180.1 was phosphorylated in planta in a
MAPK dependent manner
Holzmeister et al., Am J Physiol 1997
:
The capability of the phorbol ester PMA to activate the human AT1 promoter in VSMC via an AP-1 element suggests a prominent
role for
PKC/MAPK and Ets proteins in
AT1 regulation
Kim et al., Circulation 1998
:
These
MAPK activations, followed by AP-1 activation, are
mediated at least in part by the
AT1 receptor
Miyazaki et al., Nihon rinsho. Japanese journal of clinical medicine 1998
(Cardiovascular Diseases) :
In contrast,
AT1 leads to
MAPK activation through PKC in cardiac myocytes
Inagami et al., J Am Soc Nephrol 1999
:
In addition to its well known involvement in Gq/11 mediated vasoconstriction and its key roles in the homeostasis of electrolyte balances, the
angiotensin II type 1 (AT1) receptor activates mitogen activated protein kinase (
MAPK ) and p42/44 extracellular signal regulated kinase