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INSR — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: INSR → TNF (decreases, TNF Activity)
  Evidence: TNF also inhibits insulin signaling, thereby causing insulin resistance.55,56

Text-mined interactions from Literome

Hotamisligil et al., Exp Clin Endocrinol Diabetes 1999 (Insulin Resistance...) : However, we found an approximately 2-fold increase in insulin stimulated tyrosine phosphorylation of the insulin receptor in the muscle and adipose tissue of TNF-alpha knockout mice, suggesting that insulin receptor signalling is an important target for TNF-alpha
Matsuzawa et al., Nihon rinsho. Japanese journal of clinical medicine 2000 (Insulin Resistance...) : For example, TNF-alpha from adipocytes reduces tyrosine kinase activity of the insulin receptor in obesity
Grossi et al., Ann Periodontol 2001 (Bacterial Infections...) : In addition, TNF-alpha , a potent inhibitor of the tyrosine kinase activity of the insulin receptor , has been implicated as an etiologic factor for insulin resistance
Keller et al., Biochem Biophys Res Commun 2004 (Insulin Resistance) : TNF-alpha is linked with insulin resistance, as greater amounts of TNF are detected in muscle and adipose tissue in glycemically challenged people and TNF-alpha inhibits insulin receptor signalling
Parise et al., Arq Gastroenterol 2007 (Diabetes Mellitus, Type 2...) : Tumor necrosis factor affects insulin receptor substrate phosphorylation, resulting in decreased glucose uptake and compensatory hyperinsulinemia
Feinstein et al., J Biol Chem 1993 (Liver Neoplasms, Experimental) : Tumor necrosis factor-alpha suppresses insulin induced tyrosine phosphorylation of insulin receptor and its substrates
Storz et al., FEBS Lett 1998 : TNF downregulated insulin induced insulin receptor kinase activity and insulin induced activation of the transcription factor STAT5