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HSF1 — TNF
Text-mined interactions from Literome
Singh et al., J Biol Chem 2000
(Fever) :
These data suggest that partial activation of
HSF-1 during exposure to febrile, sub-heat shock temperatures may
block TNFalpha transcription by binding to its proximal promoter or 5'-untranslated region
Singh et al., J Biol Chem 2002
:
Mutational inactivation of this site blocks the inhibitory
effect of overexpressed
HSF-1 on activity of the minimal
TNFalpha promoter ( -85/+138 ) in Raw 264.7 murine macrophages, identifying this site as an HSF-1 dependent repressor ... This suggests that
HSF-1 might
repress TNFalpha transcription through redundant mechanisms, some of which might not require high affinity binding of HSF-1
Schett et al., Cell Death Differ 2003
(MAP Kinase Signaling System) :
TNFalpha caused transient downregulation of
HSF1 activation and hsp70 synthesis, leading to increased sensitivity to heat induced apoptosis
Mandrekar et al., J Leukoc Biol 2008
(Inflammation) :
Heat shock proteins ( hsps ) and the
heat shock transcription factor-1 ( HSF-1 ) induced by oxidative stress
regulate NF-kappaB activation and
TNF-alpha gene expression in monocytes and macrophages
Cooper et al., Am J Physiol Cell Physiol 2010
(Fever) :
Using HSF1-null mice, we confirmed that
HSF1 is
required for FRT induced repression of
TNF-alpha in vitro by LPS stimulated bone marrow derived macrophages and in vivo in mice challenged intratracheally with LPS