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CXCR2 — TNF
Text-mined interactions from Literome
Khandaker et al., Blood 1999
(Calcium Signaling) :
Metalloproteinases are involved in lipopolysaccharide- and
tumor necrosis factor-alpha mediated regulation of CXCR1 and
CXCR2 chemokine receptor expression ... The downmodulation of CXCR1 and CXCR2 by LPS and TNF-alpha was most dramatically inhibited by metalloproteinase inhibitors ; 1, 10-phenanthroline and EDTA significantly attenuated LPS- and
TNF-alpha induced loss of CXCR1 and
CXCR2 cell surface expression
Juffermans et al., J Infect Dis 2000
(Endotoxemia...) :
CXCR2 down-regulation
induced by LPS or
tumor necrosis factor-alpha in vitro was abrogated by a p38 mitogen activated protein kinase ( MAPK ) inhibitor
Tikhonov et al., Clin Exp Immunol 2001
:
Down-regulation of CXCR1 and
CXCR2 expression on human neutrophils upon activation of whole blood by S. aureus is
mediated by
TNF-alpha ... We further showed that
TNF-alpha induced decrease of CXCR1 and
CXCR2 expression was associated with lower IL-8 binding and lower CXCR1 and CXCR2 mRNA levels, and was abrogated by protease inhibitors ... We suggest that during septicemia, S. aureus may inhibit neutrophil responsiveness to IL-8 and other CXC chemokines via
TNF-alpha- mediated down-regulation of CXCR1 and
CXCR2
Quaid et al., J Trauma 2001
(Wounds, Nonpenetrating) :
CXCR2 regulation of
tumor necrosis factor-alpha adherence dependent peroxide production is significantly diminished after severe injury in human neutrophils
Liu et al., Neurobiol Aging 2010
(Alzheimer Disease) :
These data suggest that
CXCR2 overexpression in peripheral T cells is intracerebral microglial
TNF-alpha dependent and TNF-alpha primes T cells transendothelial migration in Alzheimer 's diseases
Nagarkar et al., J Immunol 2009
(Asthma...) :
We conclude that
CXCR2 is required for RV-induced neutrophilic airway inflammation and that neutrophil
TNF-alpha release is
required for airway hyperresponsiveness
Asagoe et al., J Immunol 1998
:
In contrast,
CXCR1 expression was not
affected by
TNF-alpha