Gene interactions and pathways from curated databases and text-mining

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CXCR2 — TNF

Text-mined interactions from Literome

Khandaker et al., Blood 1999 (Calcium Signaling) : Metalloproteinases are involved in lipopolysaccharide- and tumor necrosis factor-alpha mediated regulation of CXCR1 and CXCR2 chemokine receptor expression ... The downmodulation of CXCR1 and CXCR2 by LPS and TNF-alpha was most dramatically inhibited by metalloproteinase inhibitors ; 1, 10-phenanthroline and EDTA significantly attenuated LPS- and TNF-alpha induced loss of CXCR1 and CXCR2 cell surface expression
Juffermans et al., J Infect Dis 2000 (Endotoxemia...) : CXCR2 down-regulation induced by LPS or tumor necrosis factor-alpha in vitro was abrogated by a p38 mitogen activated protein kinase ( MAPK ) inhibitor
Tikhonov et al., Clin Exp Immunol 2001 : Down-regulation of CXCR1 and CXCR2 expression on human neutrophils upon activation of whole blood by S. aureus is mediated by TNF-alpha ... We further showed that TNF-alpha induced decrease of CXCR1 and CXCR2 expression was associated with lower IL-8 binding and lower CXCR1 and CXCR2 mRNA levels, and was abrogated by protease inhibitors ... We suggest that during septicemia, S. aureus may inhibit neutrophil responsiveness to IL-8 and other CXC chemokines via TNF-alpha- mediated down-regulation of CXCR1 and CXCR2
Quaid et al., J Trauma 2001 (Wounds, Nonpenetrating) : CXCR2 regulation of tumor necrosis factor-alpha adherence dependent peroxide production is significantly diminished after severe injury in human neutrophils
Liu et al., Neurobiol Aging 2010 (Alzheimer Disease) : These data suggest that CXCR2 overexpression in peripheral T cells is intracerebral microglial TNF-alpha dependent and TNF-alpha primes T cells transendothelial migration in Alzheimer 's diseases
Nagarkar et al., J Immunol 2009 (Asthma...) : We conclude that CXCR2 is required for RV-induced neutrophilic airway inflammation and that neutrophil TNF-alpha release is required for airway hyperresponsiveness
Asagoe et al., J Immunol 1998 : In contrast, CXCR1 expression was not affected by TNF-alpha