Gene interactions and pathways from curated databases and text-mining

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SOCS3 — STAT6

Pathways - manually collected, often from reviews:

  • KEGG Jak-STAT signaling pathway: STAT1/STAT2/STAT3/STAT4/STAT5A/STAT5B/STAT6 → SOCS1/SOCS2/SOCS3/SOCS4/SOCS5/SOCS7 (gene expression, expression)

Text-mined interactions from Literome

Takatori et al., J Immunol 2005 : Moreover, a reporter assay showed that a constitutively active form of Stat5a but not Stat6 activated the SOCS3 promoter
Chen et al., Proc Natl Acad Sci U S A 2006 : We show that deficiency of Socs3 in T cells had minimal effects on differentiation of T cells to the T helper ( Th ) 1 or Th2 subsets ; accordingly, Socs3 had no effect on IL-12 dependent signal transducer and activator of transcription ( Stat ) 4 phosphorylation or IL-4 dependent Stat6 phosphorylation
Albanesi et al., J Immunol 2007 : We further demonstrate that IL-4 and IL-13 activate STAT-6 and induce the suppressors of cytokine signaling (SOCS)-1 and -3