Takatori et al., J Immunol 2005
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Moreover, a reporter assay showed that a constitutively active form of Stat5a but not Stat6 activated the SOCS3 promoter
Chen et al., Proc Natl Acad Sci U S A 2006
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We show that deficiency of Socs3 in T cells had minimal effects on differentiation of T cells to the T helper ( Th ) 1 or Th2 subsets ; accordingly, Socs3 had no effect on IL-12 dependent signal transducer and activator of transcription ( Stat ) 4 phosphorylation or IL-4 dependent Stat6 phosphorylation
Albanesi et al., J Immunol 2007
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We further demonstrate that IL-4 and IL-13 activate STAT-6 and induce the suppressors of cytokine signaling (SOCS)-1 and -3