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PTP4A3 — TP53

Text-mined interactions from Literome

Min et al., Life Sci 2010 (Colorectal Neoplasms...) : To elucidate the role of PRL-3 in regulating p53 in cancer cells, we used a cell culture system to measure protein level, transcriptional level, apoptosis or localization ... Further examinations revealed that PRL-3 expression reduced the stability of p53 by inducing the transcription of p53 induced protein with a RING-H2 domain ( PIRH2 ) through early growth response ( EGR ) and by increasing the phosphorylation of mouse double minute 2 (MDM2), and then both negatively regulated p53 ... These findings demonstrated that PRL-3 , like PRL-1, can negatively regulate p53 via the activation of PIRH2 and MDM2 in cancer cells
Choi et al., Biochem Biophys Res Commun 2011 (Cell Transformation, Neoplastic) : Furthermore, FKBP38 suppresses PRL-3 mediated p53 activity and cell proliferation